Mucosal serotonin reuptake transporter expression in irritable bowel syndrome is modulated by gut microbiota via mast cell–prostaglandin E2
J Gao, T Xiong, G Grabauskas, C Owyang - Gastroenterology, 2022 - Elsevier
Background & Aims Increased colonic serotonin (5-HT) level and decreased serotonin
reuptake transporter (SERT) expression in irritable bowel syndrome (IBS) may contribute to …
reuptake transporter (SERT) expression in irritable bowel syndrome (IBS) may contribute to …
Vagus nerve stimulation reduces neuroinflammation through microglia polarization regulation to improve functional recovery after spinal cord injury
H Chen, Z Feng, L Min, W Deng, M Tan… - Frontiers in …, 2022 - frontiersin.org
Background Spinal cord injury (SCI) is a devastating disease that lacks effective treatment.
Interestingly, recent studies indicated that vagus nerve stimulation (VNS), neuromodulation …
Interestingly, recent studies indicated that vagus nerve stimulation (VNS), neuromodulation …
[HTML][HTML] Intrathecal administration of naringenin improves motor dysfunction and neuropathic pain following compression spinal cord injury in rats: relevance to its …
Background Spinal cord injury (SCI) is one of the most debilitating disorders throughout the
world, causing persistent sensory-motor dysfunction, with no effective treatment. Oxidative …
world, causing persistent sensory-motor dysfunction, with no effective treatment. Oxidative …
[HTML][HTML] The dualistic role of the purinergic P2Y12-receptor in an in vivo model of Parkinson's disease: signalling pathway and novel therapeutic targets
A Iring, A Tóth, M Baranyi, L Otrokocsi, LV Módis… - Pharmacological …, 2022 - Elsevier
Parkinson's disease (PD) is a chronic, progressive neurodegenerative condition;
characterized with the degeneration of the nigrostriatal dopaminergic pathway and …
characterized with the degeneration of the nigrostriatal dopaminergic pathway and …
Receptor-interacting protein kinase 3 inhibition relieves mechanical allodynia and suppresses NLRP3 inflammasome and NF-κB in a rat model of spinal cord injury
S Xue, Z Cao, J Wang, Q Zhao, J Han… - Frontiers in molecular …, 2022 - frontiersin.org
Background Neuroinflammation is critical in developing and maintaining neuropathic pain
after spinal cord injury (SCI). The receptor-interacting protein kinase 3 (RIPK3) has been …
after spinal cord injury (SCI). The receptor-interacting protein kinase 3 (RIPK3) has been …
[HTML][HTML] Upregulation of acid sensing ion channels is associated with esophageal hypersensitivity in GERD
Proton pump inhibitors (PPIs) are the mainstay of therapy for gastroesophageal reflux
disease (GERD) but up to 60% of patients have inadequate response to therapy. Acid …
disease (GERD) but up to 60% of patients have inadequate response to therapy. Acid …
Sigma-1 receptor increases intracellular calcium in cultured astrocytes and contributes to mechanical allodynia in a model of neuropathic pain
JG Choi, SR Choi, DW Kang, J Kim, JB Park… - Brain Research …, 2022 - Elsevier
Recent studies have revealed that glial sigma-1 receptor (Sig-1R) in the spinal cord may be
a critical factor to mediate sensory function. However, the functional role of Sig-1R in …
a critical factor to mediate sensory function. However, the functional role of Sig-1R in …
Cerium oxide nanoparticles alleviate neuropathic pain by modulating macrophage polarization in a rat SCI model
D Ban, H Yu, Z Xiang, C Li, P Yu, J Wang… - Journal of Pain …, 2022 - Taylor & Francis
Context Chronic neuropathic pain (NP) frequently occurs after spinal cord injury (SCI) but
lacks effective therapeutic options in the clinic. Numerous evidence indicates the …
lacks effective therapeutic options in the clinic. Numerous evidence indicates the …
Contribution of G-protein α-subunits to analgesia, hyperalgesia, and hyperalgesic priming induced by subanalgesic and analgesic doses of fentanyl and morphine
While opioids produce both analgesia and side effects by action at μ-opioid receptors
(MORs), at spinal and supraspinal sites, the potency of different opioids to produce these …
(MORs), at spinal and supraspinal sites, the potency of different opioids to produce these …
MicroRNA-101a-3p mimic ameliorates spinal cord ischemia/reperfusion injury
ZL Zhang, D Wang, FS Chen - Neural Regeneration Research, 2022 - journals.lww.com
Abstract miR-101a-3p is expressed in a variety of organs and tissues and plays a regulatory
role in many diseases, but its role in spinal cord ischemia/reperfusion injury remains …
role in many diseases, but its role in spinal cord ischemia/reperfusion injury remains …