The intrinsic mechanisms sensing the imbalance of energy in cells are pivotal for cell
survival under various environmental insults. AMP-activated protein kinase (AMPK) serves …

Atherosclerosis refers to a unique form of chronic proinflammatory anomaly of the
vasculature, presented as rupture-prone or occlusive lesions in arteries. In advanced stages …

Nutrient sensing and damage sensing are two fundamental processes in living organisms.
While hyperglycemia is frequently linked to diabetes-related vulnerability to microbial …

The incidence of diastolic dysfunction increases with age in both humans and mice. This is
characterized by increased passive stiffness and slower relaxation of the left ventricle. The …

Inflammation has profound but poorly understood effects on metabolism, especially in the
context of obesity and nonalcoholic fatty liver disease (NAFLD). Here, we report that hepatic …

Simple Summary AMPK is an enzyme that plays a role in cellular energy mechanisms and
controls many metabolic and physiological processes. AMPK is dysregulated in different …

In EGFR-mutant lung cancer, drug-tolerant persister cells (DTPCs) show prolonged survival
when receiving EGFR tyrosine kinase inhibitor (TKI) treatments. They are a likely source of …

There is growing evidence that mammalian cells deploy a mitochondria-associated
metabolon called the purinosome to perform channeled de novo purine biosynthesis …

Autophagy is a multi-step process regulated in part by AMP-activated protein kinase
(AMPK). Phosphorylation of threonine 172 on the AMPK α-subunit enhances AMPK kinase …

Autosomal Dominant Polycystic Kidney Disease is a genetic disease that causes dramatic
perturbations of both renal tissue architecture and of a multitude of cellular signaling …