Botulinum neurotoxins beyond neurons: Interplay with glial cells

S Luvisetto - Toxins, 2022 - mdpi.com
In recent years, numerous studies have highlighted the significant use of botulinum
neurotoxins (BoNTs) in the human therapy of various motor and autonomic disorders. The …

Sestrin2 overexpression attenuates osteoarthritis pain via induction of AMPK/PGC-1α-mediated mitochondrial biogenesis and suppression of neuroinflammation

J Sun, FH Song, JY Wu, LQ Zhang, DY Li… - Brain, behavior, and …, 2022 - Elsevier
Background Our previous study indicated that reactive oxygen species (ROS) are critically
involved in chronic pain. Sestrin2 (Sesn2), a novel stress-inducible protein, is evidenced to …

Mouse neural stem cell differentiation and human adipose mesenchymal stem cell transdifferentiation into neuron-and oligodendrocyte-like cells with myelination …

AK Santos, KN Gomes, RC Parreira, S Scalzo… - Stem Cell Reviews and …, 2022 - Springer
Stem cell therapy is an interesting approach for neural repair, once it can improve and
increase processes, like angiogenesis, neurogenesis, and synaptic plasticity. In this regard …

STING/NF-κB/IL-6-mediated inflammation in microglia contributes to spared nerve injury (SNI)-induced pain initiation

J Sun, Y Zhou, B Xu, J Li, L Zhang, D Li… - Journal of Neuroimmune …, 2022 - Springer
Innate immune response acts as the first line of host defense against damage and is initiated
following the recognition of pathogen-associated molecular patterns (PAMPs). For double …

2-Bromopalmitate decreases spinal inflammation and attenuates oxaliplatin-induced neuropathic pain via reducing Drp1-mediated mitochondrial dysfunction

ZB Dong, YJ Wang, ML Cheng, BJ Wang, H Lu, HL Zhu… - Plos one, 2022 - journals.plos.org
Oxaliplatin (OXA) is a third-generation platinum compound with clinical activity in multiple
solid tumors. Due to the repetition of chemotherapy cycle, OXA-induced chronic neuropathy …

Complex regional pain syndrome

M Stanton‐Hicks - Clinical Pain Management: A Practical Guide, 2022 - Wiley Online Library
Summary Complex Regional Pain Syndrome (CRPS), synonymous with Reflex Sympathetic
Dystrophy, has a long history. This chapter describes the diagnostic assessment and …

Exogenous TIPE2 Inhibit TAK1 to improve inflammation and neuropathic pain induced by sciatic nerve injury through inactivating NF-κB and JNK

X Sun, X Li, Y Zhou, Y Wang, X Liu - Neurochemical Research, 2022 - Springer
Tumor necrosis factor-alpha-induced protein 8-like 2 (TIPE2) possesses potent anti-
inflammatory effect. However, if TIPE2 ameliorates sciatic nerve injury (SNI)-induced …

[HTML][HTML] Nutraceuticals: A source of benefaction for neuropathic pain and fibromyalgia

G Mishra, P Singh, M Molla, YS Yimer… - Journal of Functional …, 2022 - Elsevier
Though both neuropathy and fibromyalgia are serious complications that cause widespread
pain, distinguishing between the two in order to provide adequate care is difficult. Metabolic …

[HTML][HTML] Prenatal exposure to valproic acid causes allodynia associated with spinal microglial activation

E Imado, S Sun, AR Abawa, T Tahara, T Kochi… - Neurochemistry …, 2022 - Elsevier
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits
in social communication and social interaction and the presence of restricted, repetitive …

Analgesic effect of nobiletin against neuropathic pain induced by the chronic constriction injury of the sciatic nerve in mice

C Zhu, M Tian, N Liu, L Ma, X Lan, J Yang… - Phytotherapy …, 2022 - Wiley Online Library
Neuropathic pain is chronic pain resulting from central or peripheral nerve damage that
remains difficult to treat. Current evidence suggests that nobiletin, isolated from Citrus …