Botulinum neurotoxins beyond neurons: Interplay with glial cells
S Luvisetto - Toxins, 2022 - mdpi.com
In recent years, numerous studies have highlighted the significant use of botulinum
neurotoxins (BoNTs) in the human therapy of various motor and autonomic disorders. The …
neurotoxins (BoNTs) in the human therapy of various motor and autonomic disorders. The …
Sestrin2 overexpression attenuates osteoarthritis pain via induction of AMPK/PGC-1α-mediated mitochondrial biogenesis and suppression of neuroinflammation
J Sun, FH Song, JY Wu, LQ Zhang, DY Li… - Brain, behavior, and …, 2022 - Elsevier
Background Our previous study indicated that reactive oxygen species (ROS) are critically
involved in chronic pain. Sestrin2 (Sesn2), a novel stress-inducible protein, is evidenced to …
involved in chronic pain. Sestrin2 (Sesn2), a novel stress-inducible protein, is evidenced to …
Mouse neural stem cell differentiation and human adipose mesenchymal stem cell transdifferentiation into neuron-and oligodendrocyte-like cells with myelination …
AK Santos, KN Gomes, RC Parreira, S Scalzo… - Stem Cell Reviews and …, 2022 - Springer
Stem cell therapy is an interesting approach for neural repair, once it can improve and
increase processes, like angiogenesis, neurogenesis, and synaptic plasticity. In this regard …
increase processes, like angiogenesis, neurogenesis, and synaptic plasticity. In this regard …
STING/NF-κB/IL-6-mediated inflammation in microglia contributes to spared nerve injury (SNI)-induced pain initiation
J Sun, Y Zhou, B Xu, J Li, L Zhang, D Li… - Journal of Neuroimmune …, 2022 - Springer
Innate immune response acts as the first line of host defense against damage and is initiated
following the recognition of pathogen-associated molecular patterns (PAMPs). For double …
following the recognition of pathogen-associated molecular patterns (PAMPs). For double …
2-Bromopalmitate decreases spinal inflammation and attenuates oxaliplatin-induced neuropathic pain via reducing Drp1-mediated mitochondrial dysfunction
ZB Dong, YJ Wang, ML Cheng, BJ Wang, H Lu, HL Zhu… - Plos one, 2022 - journals.plos.org
Oxaliplatin (OXA) is a third-generation platinum compound with clinical activity in multiple
solid tumors. Due to the repetition of chemotherapy cycle, OXA-induced chronic neuropathy …
solid tumors. Due to the repetition of chemotherapy cycle, OXA-induced chronic neuropathy …
Complex regional pain syndrome
M Stanton‐Hicks - Clinical Pain Management: A Practical Guide, 2022 - Wiley Online Library
Summary Complex Regional Pain Syndrome (CRPS), synonymous with Reflex Sympathetic
Dystrophy, has a long history. This chapter describes the diagnostic assessment and …
Dystrophy, has a long history. This chapter describes the diagnostic assessment and …
Exogenous TIPE2 Inhibit TAK1 to improve inflammation and neuropathic pain induced by sciatic nerve injury through inactivating NF-κB and JNK
X Sun, X Li, Y Zhou, Y Wang, X Liu - Neurochemical Research, 2022 - Springer
Tumor necrosis factor-alpha-induced protein 8-like 2 (TIPE2) possesses potent anti-
inflammatory effect. However, if TIPE2 ameliorates sciatic nerve injury (SNI)-induced …
inflammatory effect. However, if TIPE2 ameliorates sciatic nerve injury (SNI)-induced …
[HTML][HTML] Nutraceuticals: A source of benefaction for neuropathic pain and fibromyalgia
Though both neuropathy and fibromyalgia are serious complications that cause widespread
pain, distinguishing between the two in order to provide adequate care is difficult. Metabolic …
pain, distinguishing between the two in order to provide adequate care is difficult. Metabolic …
[HTML][HTML] Prenatal exposure to valproic acid causes allodynia associated with spinal microglial activation
E Imado, S Sun, AR Abawa, T Tahara, T Kochi… - Neurochemistry …, 2022 - Elsevier
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits
in social communication and social interaction and the presence of restricted, repetitive …
in social communication and social interaction and the presence of restricted, repetitive …
Analgesic effect of nobiletin against neuropathic pain induced by the chronic constriction injury of the sciatic nerve in mice
C Zhu, M Tian, N Liu, L Ma, X Lan, J Yang… - Phytotherapy …, 2022 - Wiley Online Library
Neuropathic pain is chronic pain resulting from central or peripheral nerve damage that
remains difficult to treat. Current evidence suggests that nobiletin, isolated from Citrus …
remains difficult to treat. Current evidence suggests that nobiletin, isolated from Citrus …