Ovarian cancer (OC) is the leading cause of death among women with gynecologic
malignancy. Breast Cancer Susceptibility Gene 1 (BRCA 1) and Breast Cancer Susceptibility …

Background Identifying patients with BRCA mutations is clinically important to inform on the
potential response to treatment and for risk management of patients and their relatives …

Purpose The objective of the study is to evaluate the possible association between history of
subfertility, fertility treatments, BRCA mutations and the risk of ovarian cancer. Methods This …

Aim This study aims to determine the frequency of germline BRCA 1/2 mutations in Turkish
women with epithelial ovarian cancer (EOC) and evaluate its relationship with …

Gynecologic cancers are more often caused by genetic factors than other cancers. Genetic
testing has become a promising avenue for the prevention, prognosis, and treatment of …

Epithelial ovarian cancer is responsible for the majority of gynecologic cancer deaths in the
United States, though it is only the second most common gynecologic neoplasm, accounting …

Numerous epidemiological studies examining the etiology of ovarian cancer and the role of
pregnancy related factors in ovarian cancer has been one of the topics of interest to many …

Surgery plays a critical role in the diagnosis, initial management, treatment of recurrence,
and palliation of symptoms from ovarian cancer. Surgery must be used judiciously and with …

PARP inhibitors (PARPi) play an increasing role in the treatment of ovarian cancer (OC).
However, more than 40% BRCA1/2-deficient patients do not respond to PARPi, and wild …

Mechanical forces imparted on an ovarian tumor have recently been shown to have a grave
impact on cancer development, progression, metastasis, and chemoresistance. The forces …