[HTML][HTML] Nutritional deficiency in an intestine-on-a-chip recapitulates injury hallmarks associated with environmental enteric dysfunction

A Bein, CW Fadel, B Swenor, W Cao… - Nature Biomedical …, 2022 - nature.com
Environmental enteric dysfunction (EED)—a chronic inflammatory condition of the intestine—
is characterized by villus blunting, compromised intestinal barrier function and reduced …

[HTML][HTML] Metabolomic profiling of triple negative breast cancer cells suggests that valproic acid can enhance the anticancer effect of cisplatin

A Granit, K Mishra, D Barasch… - Frontiers in Cell and …, 2022 - frontiersin.org
Cisplatin is an effective chemotherapeutic agent for treating triple negative breast cancer
(TNBC). Nevertheless, cisplatin-resistance might develop during the course of treatment …

Gut microbes shape microglia and cognitive function during malnutrition

KC Bauer, EM York, MS Cirstea, N Radisavljevic… - Glia, 2022 - Wiley Online Library
Fecal‐oral contamination promotes malnutrition pathology. Lasting consequences of early
life malnutrition include cognitive impairment, but the underlying pathology and influence of …

[HTML][HTML] Enhancement of fatty acid degradation pathway promoted glucoamylase synthesis in Aspergillus niger

J Qi, X Xiao, L Ouyang, C Yang, Y Zhuang… - Microbial Cell …, 2022 - Springer
Background Our recent multi-omics analyses of glucoamylase biosynthesis in Aspergillus
niger (A. niger) suggested that lipid catabolism was significantly up-regulated during high …

Mapping the influence of the gut microbiota on small molecules across the microbiome gut brain axis

H Hulme, LM Meikle, N Strittmatter… - Journal of the …, 2022 - ACS Publications
Microbes exert influence across the microbiome–gut–brain axis through neurotransmitter
production, induction of host immunomodulators, or the release or induction of other …

[HTML][HTML] Plasma metabolic and lipidomic fingerprinting of individuals with increased intestinal permeability

RM Shah, SR Jadhav, L Phan, K Tremellen, CD Tran… - Metabolites, 2022 - mdpi.com
The dual-sugar intestinal permeability test is a commonly used test to assess changes in gut
barrier function. However, it does not identify functional changes and the exact mechanism …

[HTML][HTML] The synergistic interaction of systemic inflammation, dysbiosis and antimicrobial resistance promotes growth restriction in children with acute severe …

R Arredondo-Hernandez, C Siebe… - Frontiers in …, 2022 - frontiersin.org
A healthy development is denied to millions of children worldwide as harsh life conditions
manifest themselves in an altered inflammation-prone microbiome crosstalk environment …

[HTML][HTML] Role of L-Carnitine supplementation on rate of weight gain and biomarkers of Environmental Enteric Dysfunction in children with severe acute malnutrition: A …

J Alam, MR Islam, SM Fahim, MA Gazi, T Ahmed - Plos one, 2022 - journals.plos.org
Background Severe acute malnutrition (SAM) and environmental enteric dysfunction (EED)
are highly prevalent among children residing in resource-limited countries like Bangladesh …

Multiomic analysis reveals microbiome-related relationships between cocaine use and metabolites

SS Martinez, V Stebliankin, J Hernandez, H Martin… - AIDS, 2022 - journals.lww.com
Objective: Over 19 million individuals globally have a cocaine use disorder, a significant
public health crisis. Cocaine has also been associated with a pro-inflammatory state and …

[PDF][PDF] Priority areas for reducing stunting in South Africa: Examining the implications of recent international evidence

R Burger, L du Plessis, T Gangaldzo, G Wills - ECD WP, 2022 - ilifalabantwana.co.za
This working paper summarises and discusses the most recent and best available
international evidence on stunting. Our aim is to inform and guide the public debate, the …