Liver organ-on-chip models for toxicity studies and risk assessment

T Messelmani, L Morisseau, Y Sakai, C Legallais… - Lab on a Chip, 2022 - pubs.rsc.org
The liver is a key organ that plays a pivotal role in metabolism and ensures a variety of
functions in the body, including homeostasis, synthesis of essential components, nutrient …

Microfluidic organ-on-a-chip devices for liver disease modeling in vitro

P Kanabekova, A Kadyrova, G Kulsharova - Micromachines, 2022 - mdpi.com
Mortality from liver disease conditions continues to be very high. As liver diseases manifest
and progress silently, prompt measures after diagnosis are essential in the treatment of …

Validation of HepG2/C3A cell cultures in cyclic olefin copolymer based microfluidic bioreactors

L Etxeberria, T Messelmani, JH Badiola, A Llobera… - Polymers, 2022 - mdpi.com
Organ-on-chip (OoC) technology is one of the most promising in vitro tools to replace the
traditional animal experiment-based paradigms of risk assessment. However, the use of …

Cyclic olefin copolymers (COC)—excellent glass formers with low dynamic fragility

R Zhang, V Madhavi, TD Shaffer… - Macromolecular …, 2022 - Wiley Online Library
Applications of cyclic olefin copolymers (COC) are manifold, and developing a complete
understanding of the characteristics of the glass transition behavior of these materials is …

Evaluation of membranes for mimicry of an alveolar-capillary barrier in microfluidic lung-on-a-chip devices

A Kadyrova, P Kanabekova, A Martin… - Materials Today …, 2022 - Elsevier
An alveolar basement membrane plays a crucial role in the organogenesis and functioning
of the lungs at the alveoli level. To emulate the function of the basement membrane in …

Development of a microfluidic device and nanofiber membranes for emulating air-blood barrier in lung-on-a-chip devices

P Kanabekova, B Dauletkanov… - 2022 IEEE 17th …, 2022 - ieeexplore.ieee.org
Here, we present the development of the first prototype of a microfluidic chip with two
compartments and a nanofiber membrane for mimicking the air-blood barrier toward …

Integration of fiber optic sensors in organ-on-a-chip devices towards label-free cell viability assays

S Shakarim, D Tosi… - 2022 IEEE Sensors …, 2022 - ieeexplore.ieee.org
In this paper, we report a microfluidic polymer organ-on-a-chip device integrated with a fiber
optic sensor towards online monitoring of cell viability on-chip. As preliminary model …

[PDF][PDF] Validation of HepG2/C3A Cell Cultures in Cyclic Olefin Copolymer Based Microfluidic Bioreactors. Polymers 2022, 14, 4478

L Etxeberria, T Messelmani, JH Badiola, A Llobera… - 2022 - hal.utc.fr
Organ-on-chip (OoC) technology is one of the most promising in vitro tools to replace the
traditional animal experiment-based paradigms of risk assessment. However, the use of …