Joint distraction, the prolonged mechanical separation of the bones at a joint, has emerged
as a joint-preserving treatment for end-stage osteoarthritis, with the gradually growing …

Objective To summarize recent scientific advances in protein-derived soluble biomarkers of
osteoarthritis. Design A systematic search on the PubMed electronic database of clinical …

During the development of the appendicular skeleton, the cartilaginous templates undergo
hypertrophic differentiation and remodels into bone, except for the cartilage most adjacent to …

Purpose The purpose of this study was to:(1) test the hypothesis that HTO improves articular
cartilage composition in the medial compartment without adversely affecting the lateral …

Osteoarthritis (OA) is a debilitating condition that significantly impacts its patients and is
closely associated with advancing age and senescence. Treatment with autologous platelet …

Objectives Knee joint distraction (KJD) has been shown to result in long-term clinical
improvement and short-term cartilage restoration in young OA patients. The objective of the …

Synovial fibrosis is a pathological process which contributes to joint pain and stiffness in
several musculoskeletal disorders. Fucoidans, sulfated polysaccharides found in brown …

Objective Increased subchondral cortical bone plate thickness and trabecular bone density
are characteristic of knee osteoarthritis (OA). Knee joint distraction (KJD) is a joint …

Background: The disruption of joint homeostasis is a critical event during the process of joint
injury in osteoarthritis (OA). As regulatory molecules, microRNAs (miRNAs) can be released …

Objective To explore mechanisms of mechanoinflammation, we investigated the association
between the presence of knee synovial perivascular edema and gait biomechanics that …