[HTML][HTML] Role of extracellular trap release during bacterial and viral infection

BM Schultz, OA Acevedo, AM Kalergis… - Frontiers in …, 2022 - frontiersin.org
Neutrophils are innate immune cells that play an essential role during the clearance of
pathogens that can release chromatin structures coated by several cytoplasmatic and …

[HTML][HTML] Mucormycosis amid COVID-19 crisis: pathogenesis, diagnosis, and novel treatment strategies to combat the spread

S Dogra, A Arora, A Aggarwal, G Passi… - Frontiers in …, 2022 - frontiersin.org
The havoc unleashed by COVID-19 pandemic has paved way for secondary ominous fungal
infections like Mucormycosis. It is caused by a class of opportunistic pathogens from the …

Global spatial dynamics and vaccine-induced fitness changes of Bordetella pertussis

N Lefrancq, V Bouchez, N Fernandes… - Science Translational …, 2022 - science.org
As with other pathogens, competitive interactions between Bordetella pertussis strains drive
infection risk. Vaccines are thought to perturb strain diversity through shifts in immune …

[HTML][HTML] Evaluation of whole-cell and acellular pertussis vaccines in the context of long-term herd immunity

E Szwejser-Zawislak, MM Wilk, P Piszczek, J Krawczyk… - Vaccines, 2022 - mdpi.com
After the pertussis vaccine had been introduced in the 1940s and was shown to be very
successful in reducing the morbidity and mortality associated with the disease, the possibility …

[HTML][HTML] Effects of epistasis and recombination between vaccine-escape and virulence alleles on the dynamics of pathogen adaptation

DV McLeod, S Gandon - Nature ecology & evolution, 2022 - nature.com
Pathogen adaptation to public health interventions such as vaccination may take tortuous
routes and involve multiple mutations at different locations in the pathogen genome, acting …

[HTML][HTML] Age and primary vaccination background influence the plasma cell response to pertussis booster vaccination

AM Diks, P Versteegen, C Teodosio, RJ Groenland… - Vaccines, 2022 - mdpi.com
Pertussis is a vaccine-preventable disease caused by the bacterium Bordetella pertussis.
Over the past years, the incidence and mortality of pertussis increased significantly. A …

Macrolide susceptibility and molecular characteristics of Bordetella pertussis

J Zhang, D Zhang, X Wang, X Wei… - Journal of International …, 2022 - journals.sagepub.com
Objective To analyse macrolide resistance and molecular characteristics of Bordetella
pertussis clinical isolates from western China, and to explore the relationship between …

[HTML][HTML] Crystal structures of pertussis toxin with NAD+ and analogs provide structural insights into the mechanism of its cytosolic ADP-ribosylation activity

M Sakari, MT Tran, J Rossjohn, AT Pulliainen… - Journal of Biological …, 2022 - ASBMB
Bordetella pertussis is the causative agent of whooping cough, a highly contagious
respiratory disease. Pertussis toxin (PT), a major virulence factor secreted by B. pertussis, is …

[HTML][HTML] A Cross-Sectional Study Revealing the Emergence of Erythromycin-Resistant Bordetella pertussis Carrying ptxP3 Alleles in China

X Wu, Q Du, D Li, L Yuan, Q Meng, Z Fu, H Xu… - Frontiers in …, 2022 - frontiersin.org
Background Previous limited studies have identified that Bordetella pertussis (B. pertussis)
isolates circulating in China possess distinct molecular features and high rates of …

[HTML][HTML] Evolution of Bordetella pertussis in the acellular vaccine era in Norway, 1996 to 2019

LT Brandal, DF Vestrheim, T Bruvik, RB Roness… - European Journal of …, 2022 - Springer
We described the population structure of Bordetella pertussis (B. pertussis) in Norway from
1996 to 2019 and determined if there were evolutionary shifts and whether these correlated …