HLA Class Ib-receptor interactions during embryo implantation and early pregnancy

LL Nilsson, TVF Hviid - Human Reproduction Update, 2022 - academic.oup.com
BACKGROUND Although the immune system intuitively must have an important role in
embryo implantation and in the achievement of a pregnancy, the molecular details have for …

[HTML][HTML] Human leukocyte antigens: the unique expression in trophoblasts and their crosstalk with local immune cells

XX Lin, YM Xie, SJ Zhao, CY Liu, G Mor… - International Journal of …, 2022 - ncbi.nlm.nih.gov
Trophoblasts differentiate and form the placenta during pregnancy in a complex and finely
orchestrated process, which is dependent on the establishment of maternal-fetal immune …

Endometrial HLA-F expression is influenced by genotypes and correlates differently with immune cell infiltration in IVF and recurrent implantation failure patients

H Papúchová, MH Saxtorph, T Hallager… - Human …, 2022 - academic.oup.com
STUDY QUESTION Is human leukocyte antigen (HLA)-F protein expressed in mid-secretory
endometrium, and are its expression levels influenced by HLA-F gene polymorphisms and …

[HTML][HTML] Advances in the study of HLA class Ib in maternal-fetal immune tolerance

Y Yang, W Wang, J Weng, H Li, Y Ma, L Liu… - Frontiers in …, 2022 - frontiersin.org
The HLA class Ib molecule is an alloantigen that causes transplant rejection on behalf of
individual human and plays an important role in maternal-fetal immune tolerance. Early …

HLA-E and HLA-F are overexpressed in glioblastoma and HLA-E increased after exposure to ionizing radiation

T Hrbac, A Kopkova, F Siegl, M Vecera… - Cancer Genomics & …, 2022 - cgp.iiarjournals.org
Background/Aim: Glioblastoma (GBM) is one of the deadliest human cancers responding
very poorly to therapy. Although the central nervous system has been traditionally …

[HTML][HTML] Sequence Variations Within HLA-G and HLA-F Genomic Segments at the Human Leukocyte Antigen Telomeric End Associated With Acute Graft-Versus …

S Suzuki, S Morishima, M Murata, M Tanaka… - Frontiers in …, 2022 - frontiersin.org
Acute graft-versus-host disease (aGVHD) is defined as a syndrome of an immunological
response of graft to the host that occurs early after allogeneic hematopoietic stem cell …

[HTML][HTML] Four Faces of cell-surface HLA Class-I: Their antigenic and immunogenic divergence generating novel targets for Vaccines

MH Ravindranath, NM Ravindranath, SR Selvan… - Vaccines, 2022 - mdpi.com
Leukocyte cell-surface HLA-I molecules, involved in antigen presentation of peptides to
CD8+ T-cells, consist of a heavy chain (HC) non-covalently linked to β2-microglobulin …

[HTML][HTML] Identification of hub genes and pathophysiological mechanism related to acute unilateral vestibulopathy by integrated bioinformatics analysis

Y Cheng, J Zheng, Y Zhan, C Liu, B Lu, J Hu - Frontiers in Neurology, 2022 - frontiersin.org
Background Although many pathological mechanisms and etiological hypotheses of acute
unilateral vestibulopathy (AUVP) have been reported, but the actual etiology remains to be …

[HTML][HTML] Role of HLA-I Structural Variants and the Polyreactive Antibodies They Generate in Immune Homeostasis

MH Ravindranath, F El Hilali, CJ Amato-Menker… - Antibodies, 2022 - mdpi.com
Cell-surface HLA-I molecules consisting of β2-microglobulin (β2m) associated heavy chains
(HCs), referred to as Face-1, primarily present peptides to CD8+ T-cells. HCs consist of three …

[HTML][HTML] Framework of Intrinsic Immune Landscape of Dormant Prostate Cancer

NKY Wong, X Dong, YY Lin, H Xue, R Wu, D Lin… - Cells, 2022 - mdpi.com
Androgen deprivation therapy (ADT) is the standard therapy for men with advanced prostate
cancer (PCa). PCa often responds to ADT and enters a dormancy period, which can be …