Primary aldosteronism is a common cause of hypertension and is a risk factor for
cardiovascular and renal morbidity and mortality, via mechanisms mediated by both …

We are witnessing a revolution in our understanding of primary aldosteronism (PA). In the
past 2 decades, we have learned that PA is a highly prevalent syndrome that is largely …

Hypertension is the most important modifiable cause of cardiovascular (CV) disease and all-
cause mortality worldwide. Despite the positive correlations between blood pressure (BP) …

Antihypertensive drug therapy is one of the most efficient medical interventions for
preventing disability and death globally. Most of the evidence supporting its benefits has …

Regulated Na+ transport in the distal nephron is of fundamental importance to fluid and
electrolyte homeostasis. Further upstream, Na+ is the principal driver of secondary active …

Most hypertensive cases are primary and heavily associated with modifiable risk factors like
salt intake. Evidence suggests that even small reductions in salt consumption reduce blood …

Despite existing treatments, patients with heart failure and chronic kidney disease (CKD)
remain at high risk for adverse outcomes and progression to end-stage disease. Steroidal …

Hypertension is the most frequent chronic and non-communicable disease all over the
world, with about 1.5 billion affected individuals worldwide. Its impact is currently growing …

Arterial hypertension is one of the major causes of cardiovascular morbidity and mortality
worldwide. Effective and sustained reduction in blood pressure is essential to reduce …

Background: MR (mineralocorticoid receptor) antagonists are recommended for patients
with resistant hypertension even when circulating aldosterone levels are not high. Although …