Pulmonary surfactant is critically important to prevent atelectasis by lowering the surface
tension of the alveolar lining liquid. While respiratory distress syndrome (RDS) is common in …

Pulmonary surfactant is a complex lipoprotein mixture secreted into the alveolar lumen by
type 2 pneumocytes, which is composed by tens of different lipids (approximately 90% of its …

The assembly of proteins and peptides into amyloid fibrils is causally linked to serious
disorders such as Alzheimer's disease. Multiple proteins have been shown to prevent …

Genetic disorders of surfactant dysfunction result in significant morbidity and mortality,
among infants, children, and adults. Available medical interventions are limited, nonspecific …

Acute inflammatory exacerbations (AIEs) represent immune-driven deteriorations of many
chronic lung conditions, including COPD, asthma, and pulmonary fibrosis (PF). The first line …

Objective: To analyze the etiology of chest diffuse radiological changes (DRC) in children
older than 2 years. Methods A retrospective study was conducted on a primary cohort of …

Objectives This study aims to describe the molecular variability in the SFTPC gene in a
childhood chronic respiratory disease, asthma, in the Tunisian population and to identify the …

In accordance with the present invention, compositions and a CRISPR-Cas system-
mediated genome editing method are disclosed. An exemplary method comprises …