Platelet transfusions are commonly administered for the prevention or treatment of bleeding
in patients with acquired thrombocytopenia across a range of clinical contexts. Recent data …

Oxygen is needed to generate aerobic adenosine triphosphate and energy that is required
to support vital cellular functions. Oxygen delivery (DO 2) to the tissues is determined by …

Background Impact of in-ICU transfusion on long-term outcomes remains unknown. The
purpose of this study was to assess in critical-care survivors the association between in-ICU …

Background Anaemia is common and associated with poor outcomes in survivors of critical
illness. However, the optimal treatment strategy is unclear. Methods We conducted a …

Introduction Traumatic brain injury (TBI) is the leading cause of mortality and long-term
disability in young adults. Despite the high prevalence of anaemia and red blood cell …

2.1. Study design This systematic review with meta‐analyses and trial sequential analyses
(TSA) was registered in the International Prospective Register of Systematic Reviews …

Introduction The role of erythrocytes in the acute coronary syndrome (ACS) is complex. The
aim of this review in terms of PICO (P: patients; I: intervention; C: comparison; O: outcome) …

OBJECTIVES: Tranexamic acid is proposed as a treatment for gastrointestinal bleeding. The
Haemorrhage Alleviation with Tranexamic Acid-Intestinal System trial evaluated extended …

Our objective was to systematically evaluate the efficacy and safety of intravenous (IV) iron
therapy for treating anaemia in critically ill adults (> 16 years) admitted to intensive care or …

OBJECTIVES: In the general critical care patient population, restrictive transfusion regimen
of RBCs has been shown to be safe and is yet implemented worldwide. However, in patients …