[HTML][HTML] The potential roles of JAK/STAT signaling in the progression of osteoarthritis

Q Zhou, Q Ren, L Jiao, J Huang, J Yi, J Chen… - Frontiers in …, 2022 - frontiersin.org
Osteoarthritis (OA) is an age-related chronic progressive degenerative disease that induces
persistent pain and disabilities. The development of OA is a complex process, and the risk …

[HTML][HTML] Genetic, cellular and molecular aspects involved in apical periodontitis

IBF Petean, AC Silva-Sousa, TJ Cronenbold… - Brazilian Dental …, 2022 - SciELO Brasil
The development, establishment and repair of apical periodontitis (AP) is dependent of
several factors, which include host susceptibility, microbial infection, immune response …

RPL38 knockdown inhibits the inflammation and apoptosis in chondrocytes through regulating METTL3-mediated SOCS2 m6A modification in osteoarthritis

L Shi, H Hu, P Sun, Z Li, L Ji, S Liu, J Zhang - Inflammation Research, 2022 - Springer
Abstract Background Ribosomal protein L38 (RPL38) was found upregulated in
osteoarthritic peripheral blood mononuclear cells, however, its role in progression of …

[HTML][HTML] The gene signature of activated M-CSF-primed human monocyte-derived macrophages is IL-10-dependent

VD Cuevas, M Simón-Fuentes, E Orta-Zavalza… - Journal of Innate …, 2022 - karger.com
During inflammatory responses, monocytes are recruited into inflamed tissues, where they
become monocyte-derived macrophages and acquire pro-inflammatory and tissue …

3D chromatin structure in chondrocytes identifies putative osteoarthritis risk genes

E Thulson, ES Davis, S D'Costa, PR Coryell… - Genetics, 2022 - academic.oup.com
Genome-wide association studies have identified over 100 loci associated with osteoarthritis
risk, but the majority of osteoarthritis risk variants are noncoding, making it difficult to identify …

SOCS2 regulation of growth hormone signaling requires a canonical interaction with phosphotyrosine

K Li, LG Meza Guzman, L Whitehead… - Bioscience …, 2022 - portlandpress.com
Suppressor of cytokine signaling (SOCS) 2 is the critical negative regulator of growth
hormone (GH) and prolactin signaling. Mice lacking SOCS2 display gigantism with …

[HTML][HTML] The role of accelerated growth plate fusion in the absence of SOCS2 on osteoarthritis vulnerability

HJ Samvelyan, C Huesa, L Cui… - Bone & Joint …, 2022 - boneandjoint.org.uk
Aims Osteoarthritis (OA) is the most prevalent systemic musculoskeletal disorder,
characterized by articular cartilage degeneration and subchondral bone (SCB) sclerosis …

Du métabolisme énergétique des chondrocytes arthrosiques jusqu'au développement d'un outil de vectorisation

A Defois-Le Menn - 2022 - theses.hal.science
L'arthrose est la plus commune des maladies articulaires. Malgré plus de 500 millions de
personnes atteintes dans le monde, et une incidence grandissante avec le vieillissement de …