GLUT4 is the primary glucose transporter in adipose and skeletal muscle tissues. Its cellular
trafficking is regulated by insulin signaling. Failed or reduced plasma membrane localization …

Diabetes is a global epidemic, of which type 2 diabetes makes up the majority of cases.
Nonetheless, for some individuals, type 2 diabetes is eminently preventable and treatable …

Skeletal muscle and adipose tissue insulin resistance are major drivers of metabolic
disease. To uncover pathways involved in insulin resistance, specifically in these tissues, we …

Insulin rapidly stimulates GLUT4 translocation and glucose transport in fat and muscle cells.
Signals from the occupied insulin receptor are translated into downstream signalling …

Earlier we had reviewed the role of herbal treatment, epigenetic modes, other mechanistic
pathophysiological roles like macrophage polarization, epigenetics, role of adipokines …

Insulin-stimulated translocation of glucose transporter 4 (GLUT4) to plasma membrane of
skeletal muscle is critical for postprandial glucose uptake; however, whether the …

Intramuscular implantation of cultured allogeneic myoblasts derived from pathogen-free
muscle biopsies of genetically normal human volunteers demonstrated safety and efficacy in …

Insulin resistance (IR) is a condition in which insulin-mediated regulation of glucose
metabolism in body tissues (primarily liver, adipose tissue and skeletal muscle) becomes …

Аннотация В медицинской литературе отсутствуют концептуальные работы по
изучению энергетических потребностей при тяжелых заболеваниях, травматических …

Abstract Currently, glucose transporter 4 (GLUT4) has been considered as the key player for
the insulin-stimulated glucose transport in the muscle and adipose tissues. The …