Vitamin B12 or cobalamin deficiency is a commonly encountered clinical scenario and most
clinicians will have familiarity prescribing Vitamin B12 to treat their patients. Despite the high …

ATP‐binding cassette (ABC) superfamily is one of the largest groups of primary active
transporters that could be found in all kingdoms of life from bacteria to humans. In humans …

Human ABC transporter ABCD1 transports very long-chain fatty acids from cytosol to
peroxisome for β-oxidation, dysfunction of which usually causes the X-linked …

Inherited disorders of B 12 metabolism produce a broad spectrum of manifestations, with
limited knowledge of the influence of age and the function of related genes. We report a …

Abstract Vitamin B 12 (cobalamin, Cbl, B 12) is a water-soluble micronutrient synthesized
exclusively by a group of microorganisms. Human beings are unable to make B 12 and thus …

A wide variety of organisms encode cobalamin-dependent enzymes catalyzing essential
metabolic reactions, but the cofactor cobalamin (vitamin B12) is only synthesized by a …

The peroxisomal very long chain fatty acid (VLCFA) transporter ABCD1 is central to fatty acid
catabolism and lipid biosynthesis. Its dysfunction underlies toxic cytosolic accumulation of …

The ATP-binding cassette (ABC) transporters are one of the largest families of membrane-
bound proteins and exist in almost all living organisms from eubacteria to mammals. They …

Nutritional deficiency and genetic errors that impair the transport, absorption, and utilization
of vitamin B 12 (B 12) lead to hematological and neurological manifestations. The cblC …

Adrenoleukodystrophy protein (ALDP) is responsible for the transport of very-long-chain fatty
acids (VLCFAs) and corresponding CoA-esters across the peroxisomal membrane …