[PDF][PDF] A TLR4-independent critical role for CD14 in intracellular LPS sensing

SO Vasudevan, AJ Russo, P Kumari, SK Vanaja… - Cell reports, 2022 - cell.com
Intracellular lipopolysaccharide (LPS) sensing by the noncanonical inflammasome
comprising caspase-4 or-11 governs antibacterial host defense. How LPS gains intracellular …

Engineered platelet microparticle-membrane camouflaged nanoparticles for targeting the golgi apparatus of synovial fibroblasts to attenuate rheumatoid arthritis

C Deng, X Zhao, Y Chen, K Ai, Y Zhang, T Gong… - ACS …, 2022 - ACS Publications
Synovial fibroblasts in rheumatoid arthritis (RA) joints mediate synovial hyperplasia,
progressive joint destruction, and the potential spread of disease between joints by …

[HTML][HTML] Macrophages in periapical lesions: potential roles and future directions

Y Song, X Li, D Huang, H Song - Frontiers in Immunology, 2022 - frontiersin.org
Periapical lesions are infectious diseases that occur in the apical region of teeth. They result
in the destruction of alveolar bone and are usually accompanied by swelling, pain, and …

CD14 recycling modulates LPS‐induced inflammatory responses of murine macrophages

A Ciesielska, M Krawczyk, H Sas‐Nowosielska… - Traffic, 2022 - Wiley Online Library
TLR4 is activated by the bacterial endotoxin lipopolysaccharide (LPS) and triggers two
proinflammatory signaling cascades: a MyD88‐dependent one in the plasma membrane …

Negative cross-talk between TLR2/4-independent AMPKα1 and TLR2/4-dependent JNK regulates S. Pneumoniae–induced mucosal innate immune response

S Matsuyama, K Komatsu, BC Lee, Y Tasaki… - The Journal of …, 2022 - journals.aai.org
Streptococcus pneumoniae is major cause of otitis media (OM) and life-threatening
pneumonia. Overproduction of mucin, the major component of mucus, plays a critical role in …

Analiza struktury i funkcji białka MyD88 zaangażowanego w odpowiedź immunologiczną

K Kuśka - 2022 - ruj.uj.edu.pl
Białko MyD88 (ang. Myeloid differentiation primary response 88) uważane jest za jedno z
kluczowych białek adaptorowych wrodzonej odpowiedzi immunologicznej, które łączy …