Gut-liver axis: Pathophysiological concepts and clinical implications
H Tilg, TE Adolph, M Trauner - Cell metabolism, 2022 - cell.com
Bidirectional crosstalk along the gut-liver axis controls gastrointestinal health and disease
and exploits environmental and host mediators. Nutrients, microbial antigens, metabolites …
and exploits environmental and host mediators. Nutrients, microbial antigens, metabolites …
Developing dietary interventions as therapy for cancer
SR Taylor, JN Falcone, LC Cantley… - Nature Reviews …, 2022 - nature.com
Cancer cells acquire distinct metabolic preferences based on their tissue of origin, genetic
alterations and degree of interaction with systemic hormones and metabolites. These …
alterations and degree of interaction with systemic hormones and metabolites. These …
[HTML][HTML] Randomized controlled trial for time-restricted eating in healthy volunteers without obesity
Z Xie, Y Sun, Y Ye, D Hu, H Zhang, Z He… - Nature …, 2022 - nature.com
Time-restricted feeding (TRF) improves metabolic health. Both early TRF (eTRF, food intake
restricted to the early part of the day) and mid-day TRF (mTRF, food intake restricted to the …
restricted to the early part of the day) and mid-day TRF (mTRF, food intake restricted to the …
Fasting-mimicking diet is safe and reshapes metabolism and antitumor immunity in patients with cancer
C Vernieri, G Fucà, F Ligorio, V Huber, A Vingiani… - Cancer Discovery, 2022 - AACR
In tumor-bearing mice, cyclic fasting or fasting-mimicking diets (FMD) enhance the activity of
antineoplastic treatments by modulating systemic metabolism and boosting antitumor …
antineoplastic treatments by modulating systemic metabolism and boosting antitumor …
[HTML][HTML] Dietary regulation in health and disease
Nutriments have been deemed to impact all physiopathologic processes. Recent evidences
in molecular medicine and clinical trials have demonstrated that adequate nutrition …
in molecular medicine and clinical trials have demonstrated that adequate nutrition …
[HTML][HTML] Soluble TREM2 levels reflect the recruitment and expansion of TREM2+ macrophages that localize to fibrotic areas and limit NASH
T Hendrikx, F Porsch, MG Kiss, D Rajcic… - Journal of …, 2022 - Elsevier
Background & Aims Previous single-cell RNA-sequencing analyses have shown that Trem2-
expressing macrophages are present in the liver during obesity, non-alcoholic …
expressing macrophages are present in the liver during obesity, non-alcoholic …
Immune and non-immune functions of adipose tissue leukocytes
Adipose tissue is a complex dynamic organ with whole-body immunometabolic influence.
Much of the work into understanding the role of immune cells in adipose tissue has been in …
Much of the work into understanding the role of immune cells in adipose tissue has been in …
[HTML][HTML] Control of immunity via nutritional interventions
Nutrition affects all physiological processes including those linked to the development and
function of our immune system. Here, we discuss recent evidence and emerging concepts …
function of our immune system. Here, we discuss recent evidence and emerging concepts …
[HTML][HTML] Immunometabolic rewiring in tumorigenesis and anti-tumor immunotherapy
X Lian, K Yang, R Li, M Li, J Zuo, B Zheng, W Wang… - Molecular Cancer, 2022 - Springer
Cellular metabolism constitutes a fundamental process in biology. During tumor initiation
and progression, each cellular component in the cancerous niche undergoes dramatic …
and progression, each cellular component in the cancerous niche undergoes dramatic …
Vitamin E enhances cancer immunotherapy by reinvigorating dendritic cells via targeting checkpoint SHP1
Despite the popular use of dietary supplements during conventional cancer treatments, their
impacts on the efficacies of prevalent immunotherapies, including immune-checkpoint …
impacts on the efficacies of prevalent immunotherapies, including immune-checkpoint …