On‐tissue chemical derivatization in mass spectrometry imaging

C Harkin, KW Smith, FL Cruickshank… - Mass spectrometry …, 2022 - Wiley Online Library
Mass spectrometry imaging (MSI) combines molecular and spatial information in a valuable
tool for a wide range of applications. Matrix‐assisted laser desorption/ionization (MALDI) is …

Rapidity and precision of steroid hormone measurement

S Karashima, I Osaka - Journal of clinical medicine, 2022 - mdpi.com
Steroids are present in all animals and plants, from mammals to prokaryotes. In the medical
field, steroids are commonly classified as glucocorticoids, mineralocorticoids, and gonadal …

Three‐dimensional quantitative mass spectrometry imaging in complex system: From subcellular to whole organism

C Zhao, Z Cai - Mass spectrometry reviews, 2022 - Wiley Online Library
Mass spectrometry imaging (MSI) has been applied for label‐free three‐dimensional (3D)
imaging from position array across the whole organism, which provides high‐dimensional …

Molecular networking and on-tissue chemical derivatization for enhanced identification and visualization of steroid glycosides by MALDI mass spectrometry imaging

D Dreisbach, S Heiles, DR Bhandari… - Analytical …, 2022 - ACS Publications
Spatial metabolomics describes the spatially resolved analysis of interconnected pathways,
biochemical reactions, and transport processes of small molecules in the spatial context of …

Spatial localization of β-unsaturated aldehyde markers in murine diabetic kidney tissue by mass spectrometry imaging

C Harkin, KW Smith, CL MacKay, T Moore… - Analytical and …, 2022 - Springer
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. Limitations in
current diagnosis and screening methods have sparked a search for more specific and …

Isoflurane stress induces region-specific glucocorticoid levels in neonatal mouse brain

JE Hamden, KM Gray, M Salehzadeh… - Journal of …, 2022 - joe.bioscientifica.com
The profound programming effects of early life stress (ELS) on brain and behavior are
thought to be primarily mediated by adrenal glucocorticoids (GCs). However, in mice …

Rapid and automatic annotation of multiple on-tissue chemical modifications in mass spectrometry imaging with metaspace

EA Larson, TT Forsman, L Stuart… - Analytical …, 2022 - ACS Publications
On-tissue chemical derivatization is a valuable tool for expanding compound coverage in
untargeted metabolomic studies with matrix-assisted laser desorption/ionization mass …

Mapping the Heterogeneous Distribution of Cancer Drugs by Imaging Mass Spectrometry

PS DAMALE, S BANERJEE - Drug Metabolism Handbook …, 2022 - Wiley Online Library
The complex neoplastic tissue and its microenvironment often posit intratumor
heterogeneity, affecting drug molecule distribution in the tumor. A deep understanding of the …