COVID-19 in pregnancy: implications for fetal brain development

LL Shook, EL Sullivan, JO Lo, RH Perlis… - Trends in molecular …, 2022 - cell.com
The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
during pregnancy on the developing fetal brain is poorly understood. Other antenatal …

Immune dysregulation in autism spectrum disorder: what do we know about it?

MA Robinson-Agramonte, E Noris García… - International journal of …, 2022 - mdpi.com
Autism spectrum disorder (ASD) is a group of complex multifactorial neurodevelopmental
disorders characterized by a wide and variable set of neuropsychiatric symptoms, including …

Maternal inflammation and its ramifications on fetal neurodevelopment

HK Kwon, GB Choi, JR Huh - Trends in immunology, 2022 - cell.com
Exposure to heightened inflammation in pregnancy caused by infections or other
inflammatory insults has been associated with the onset of neurodevelopmental and …

Virus-induced maternal immune activation as an environmental factor in the etiology of autism and schizophrenia

A Massrali, D Adhya, DP Srivastava… - Frontiers in …, 2022 - frontiersin.org
Maternal immune activation (MIA) is mediated by activation of inflammatory pathways
resulting in increased levels of cytokines and chemokines that cross the placental and blood …

Neurodevelopmental outcomes of infants born to mothers with SARS-CoV-2 infections during pregnancy: a national prospective study in Kuwait

M Ayed, A Embaireeg, M Kartam, K More, M Alqallaf… - BMC pediatrics, 2022 - Springer
Background An increasing proportion of women are infected with severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) during pregnancy. Intrauterine viral infections …

Differential effects of early or late exposure to prenatal maternal immune activation on mouse embryonic neurodevelopment

E Guma, M Bordeleau… - Proceedings of the …, 2022 - National Acad Sciences
Exposure to maternal immune activation (MIA) in utero is a risk factor for
neurodevelopmental and psychiatric disorders. MIA-induced deficits in adolescent and adult …

Consequences of viral infection and cytokine production during pregnancy on brain development in offspring

D Elgueta, P Murgas, E Riquelme, G Yang… - Frontiers in …, 2022 - frontiersin.org
Infections during pregnancy can seriously damage fetal neurodevelopment by aberrantly
activating the maternal immune system, directly impacting fetal neural cells. Increasing …

Prenatal environmental stressors impair postnatal microglia function and adult behavior in males

CL Block, O Eroglu, SD Mague, CJ Smith, AM Ceasrine… - Cell reports, 2022 - cell.com
Gestational exposure to environmental toxins and socioeconomic stressors is
epidemiologically linked to neurodevelopmental disorders with strong male bias, such as …

Modifying the maternal microbiota alters the gut–brain metabolome and prevents emotional dysfunction in the adult offspring of obese dams

DE Radford-Smith, F Probert… - Proceedings of the …, 2022 - National Acad Sciences
Maternal obesity disturbs brain–gut–microbiota interactions and induces negative affect in
the offspring, but its impact on gut and brain metabolism in the offspring (F1) are unknown …

SARS-CoV-2 (COVID-19) as a possible risk factor for neurodevelopmental disorders

H Dubey, RK Sharma, S Krishnan… - Frontiers in …, 2022 - frontiersin.org
Pregnant women constitute one of the most vulnerable populations to be affected by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the cause of coronavirus …