[HTML][HTML] CNS pharmacology of NKCC1 inhibitors
W Loescher, K Kaila - Neuropharmacology, 2022 - Elsevier
Abstract The Na–K–2Cl cotransporter NKCC1 and the neuron-specific K–Cl cotransporter
KCC2 are considered attractive CNS drug targets because altered neuronal chloride …
KCC2 are considered attractive CNS drug targets because altered neuronal chloride …
Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide
Cation-chloride cotransporters (CCCs) NKCC1 and NKCC2 catalyze electroneutral symport
of 1 Na+, 1 K+, and 2 Cl− across cell membranes. NKCC1 mediates trans-epithelial Cl …
of 1 Na+, 1 K+, and 2 Cl− across cell membranes. NKCC1 mediates trans-epithelial Cl …
Toward understanding the diverse roles of perisomatic interneurons in epilepsy
Epileptic seizures are associated with excessive neuronal spiking. Perisomatic γ-
aminobutyric acid (GABA) ergic interneurons specifically innervate the subcellular domains …
aminobutyric acid (GABA) ergic interneurons specifically innervate the subcellular domains …
Structure of the human cation–chloride cotransport KCC1 in an outward-open state
Cation–chloride cotransporters (CCCs) catalyze electroneutral symport of Cl− with Na+
and/or K+ across membranes. CCCs are fundamental in cell volume homeostasis …
and/or K+ across membranes. CCCs are fundamental in cell volume homeostasis …
[HTML][HTML] KCC2 drives chloride microdomain formation in dendritic blebbing
Intracellular chloride ion concentration ([Cl–] i) homeostasis is critical for excitatory/inhibitory
balance and volume regulation in neurons. We quantitatively map spatiotemporal dendritic …
balance and volume regulation in neurons. We quantitatively map spatiotemporal dendritic …
Loss of KCC2 in GABAergic neurons causes seizures and an imbalance of cortical interneurons
K Zavalin, A Hassan, C Fu, E Delpire… - Frontiers in Molecular …, 2022 - frontiersin.org
K-Cl transporter KCC2 is an important regulator of neuronal development and neuronal
function at maturity. Through its canonical transporter role, KCC2 maintains inhibitory …
function at maturity. Through its canonical transporter role, KCC2 maintains inhibitory …
[HTML][HTML] The effect of valproic acid and furosemide on the regulation of the inflammasome complex (NLRP1 and NLRP3 mRNA) in the brain of epileptic animal model
A Samadianzakaria, Z Abdolmaleki… - Brain Research Bulletin, 2022 - Elsevier
Objectives This study aimed to explore the effect of concomitant use of Furosemide (FRS)
and Valproic acid (VPA), demonstrating anti-inflammation efficacy, on epilepsy, and its …
and Valproic acid (VPA), demonstrating anti-inflammation efficacy, on epilepsy, and its …
Lacosamide decreases neonatal seizures without increasing apoptosis
Objective Many seizing neonates fail to respond to first‐line anticonvulsant medications.
Phenobarbital, an allosteric modulator of γ‐aminobutyric acid type A (GABAA) receptors, has …
Phenobarbital, an allosteric modulator of γ‐aminobutyric acid type A (GABAA) receptors, has …
Clarifications regarding bumetanide for neonatal seizures
KJ Staley - Epilepsia, 2022 - Wiley Online Library
A recent Phase II randomized, controlled trial of bumetanide as an adjunctive treatment for
neonatal seizures showed a robust efficacy signal and no evidence of toxicity. Concerns …
neonatal seizures showed a robust efficacy signal and no evidence of toxicity. Concerns …
Displacement of extracellular chloride by sulfated glycosaminoglycans of the brain's extracellular matrix
KP Normoyle, KP Lillis, K Egawa, MA McNally… - BioRxiv, 2022 - biorxiv.org
GABA is the primary inhibitory neurotransmitter. Membrane currents evoked by GABAA
receptor activation have uniquely small driving forces: their reversal potential (EGABA) is …
receptor activation have uniquely small driving forces: their reversal potential (EGABA) is …