1University of Pisa and University Cardiology Division, Pisa University Hospital, Pisa, Italy;
and 2Fondazione VillaSerena per la Ricerca, Città Sant'Angelo, Pescara, Italy How to best …

Introduction: There is uncertainty regarding the optimal timing for initiation of oral
anticoagulation in patients with acute ischemic stroke (AIS) due to atrial fibrillation (AF) …

Background Antithrombotic drugs increase the risk of bleeding, especially in patients who
need urgent surgery without an adequate wash-out period. This review aims to evaluate …

Abstract Background Direct oral anticoagulants (DOACs) have become preferable for the
management of thromboembolic events. Recent publications have however identified high …

The management of patients on direct oral anticoagulants (DOACs) who require emergent
cardiac surgery is slowly evolving. The introduction of andexanet alfa, a novel antidote for …

Trauma-induced pulmonary thromboembolism is the second leading cause of death in
severe trauma patients. Primary fibrinolytic hyperactivity combined with hemorrhage and …

Aim To conduct a cost-effectiveness analysis (CEA) on the use of andexanet alfa for the
treatment of factor Xa inhibitor-related intracranial hemorrhage (ICH) from the US third-party …

The mechanism underlying large individual differences in the response to oral
anticoagulants has not been fully clarified, and the influence of the intestinal microbiome on …

Background Knowledge about atrial fibrillation (AF) and oral anticoagulation (OAC) is
insufficient among AF patients. Objective We examined the association between this …

Objective The study of ABCB1 and CYP3A4/3A5 gene polymorphism genes is promising in
terms of their influence on prothrombin time variability, the residual equilibrium …