The history of brain drug delivery is reviewed beginning with the first demonstration, in 1914,
that a drug for syphilis, salvarsan, did not enter the brain, due to the presence of a blood …

Ischemic stroke and traumatic brain injury (TBI) are among the leading causes of death and
disability worldwide with impairments ranging from mild to severe. Many therapies are …

Brain-derived neurotrophic factor is an extensively studied neurotrophin implicated in the
pathology of multiple neurodegenerative and psychiatric disorders including, but not limited …

Importance Clinical trial activity in amyotrophic lateral sclerosis (ALS) is dramatically
increasing; as a result, trial modifications have been introduced to improve efficiency …

Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family of secreted
growth factors and binds with high affinity to the TrkB tyrosine kinase receptors. BDNF is a …

Neurotrophin is a growth factor that regulates the development and repair of the nervous
system. From all factors, two pioneer groups, the nerve growth factor (NGF) and brain …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder that still
lacks an efficient therapy. The barriers between the central nervous system (CNS) and the …

Traumatic spinal cord injuries (SCI) leave people with life changing disabilities including
paralysis. There is a high probability that the circuitry below the injury responds in a …

Provided herein are methods and compositions for treating a subject suffering from a
deficiency in oL-Iduronidase in the CNS. The methods include systemic administration of a …

There is provided herein a compound of formula (I) wherein R 1, R 2, n, X, Q, L, m, R 3 and p
are as defined herein, which compounds are useful in the treatment of treatment of diseases …