Limitations and opportunities of technologies for the analysis of cell-free DNA in cancer diagnostics

P Song, LR Wu, YH Yan, JX Zhang, T Chu… - Nature biomedical …, 2022 - nature.com
Cell-free DNA (cfDNA) in the circulating blood plasma of patients with cancer contains
tumour-derived DNA sequences that can serve as biomarkers for guiding therapy, for the …

Integrating circulating-free DNA (cfDNA) analysis into clinical practice: opportunities and challenges

M Garcia-Pardo, M Makarem, JJN Li, D Kelly… - British Journal of …, 2022 - nature.com
In the current era of precision medicine, the identification of genomic alterations has
revolutionised the management of patients with solid tumours. Recent advances in the …

The current state of molecular profiling in gastrointestinal malignancies

R Mukherji, C Yin, R Hameed, AZ Alqahtani… - Biology Direct, 2022 - Springer
This is a review of the current state of molecular profiling in gastrointestinal (GI) cancers and
what to expect from this evolving field in the future. Individualized medicine is moving from …

[HTML][HTML] Use of circulating tumour DNA to assess minimal residual disease in gastrointestinal cancers

R Mukherji, A Alqahtani, HD Winters, BA Weinberg - 1, 2022 - touchoncology.com
Overview Despite our modern perioperative therapies, many patients with gastrointestinal
cancer relapse after surgery. Novel strategies to identify and treat patients at high risk of …

Updates in the Treatment of Patients With Colorectal Cancer

SS Krishnamurthi - Journal of the National Comprehensive Cancer …, 2022 - jnccn.org
A number of assays are now available to estimate the prognosis of early-stage colorectal
cancer, including multigene assays, the Immunoscore, and circulating tumor DNA (ctDNA) …