TCR-T immunotherapy: the challenges and solutions

Y Liu, X Yan, F Zhang, X Zhang, F Tang, Z Han… - Frontiers in …, 2022 - frontiersin.org
T cell receptor-engineered T cell (TCR-T) therapy is free from the limit of surface antigen
expression of the target cells, which is a potential cellular immunotherapy for cancer …

Immune reconstitution after allogeneic haematopoietic cell transplantation: from observational studies to targeted interventions

A Yanir, A Schulz, A Lawitschka, S Nierkens… - Frontiers in …, 2022 - frontiersin.org
Immune reconstitution (IR) after allogeneic haematopoietic cell transplantation (HCT)
represents a central determinant of the clinical post-transplant course, since the majority of …

CD146 defines a mesenchymal stromal cell subpopulation with enhanced suppressive properties

JP Bikorimana, W Saad, J Abusarah, M Lahrichi… - Cells, 2022 - mdpi.com
Mesenchymal stromal cells (MSCs) are largely known for their immune-suppressive
capacity, hence, their common use in the control of unwanted inflammation. However, novel …

[HTML][HTML] A Notch/IL-21 signaling axis primes bone marrow T cell progenitor expansion

K Sottoriva, NY Paik, Z White, T Bandara, L Shao… - JCI insight, 2022 - ncbi.nlm.nih.gov
Long-term impairment in T cell–mediated adaptive immunity is a major clinical obstacle
following treatment of blood disorders with hematopoietic stem cell transplantation. Although …

Effects of Soy–Whey Protein Nutritional Supplementation on Hematopoiesis and Immune Reconstitution in an Allogeneic Transplanted Mice

X Wu, Q Hou, Z Zhao, J Wang, Y Guo, L Lu, J Han - Nutrients, 2022 - mdpi.com
Profound malnutrition and immunodeficiency are serious negative effects of radiotherapy
and bone marrow transplantation for hematologic malignancy patients. This study aimed to …

Cushing syndrome and glucocorticoids: T-cell lymphopenia, apoptosis, and rescue by IL-21

SJ Hwang, C Tatsi, HS Kuehn, JE Niemela… - Journal of Allergy and …, 2022 - Elsevier
Background Pediatric endogenous Cushing syndrome (eCs) is mainly caused by pituitary
corticotropin–producing adenomas, and most glucocorticoid-dependent effects …

[PDF][PDF] Advanced article

A Alsharif, AP Chidgey - researchgate.net
The thymus is the major site of T-lymphocyte production. Nonlymphoid elements, referred to
as the thymic stroma, create the thymic microenvironment required to govern differentiation …