PP2A and its inhibitors in helper T-cell differentiation and autoimmunity
Protein phosphatase 2A (PP2A) is a highly complex heterotrimeric Ser/Thr phosphatase that
regulates many cellular processes. The role of PP2A as a tumor suppressor has been …
regulates many cellular processes. The role of PP2A as a tumor suppressor has been …
PP2A is a therapeutically targetable driver of cell fate decisions via a c-Myc/p21 axis in human and murine acute myeloid leukemia
Dysregulated cellular differentiation is a hallmark of acute leukemogenesis. Phosphatases
are widely suppressed in cancers but have not been traditionally associated with …
are widely suppressed in cancers but have not been traditionally associated with …
Phospho-heavy-labeled-spiketide FAIMS stepped-CV DDA (pHASED) provides real-time phosphoproteomics data to aid in cancer drug selection
Global high-throughput phosphoproteomic profiling is increasingly being applied to cancer
specimens to identify the oncogenic signaling cascades responsible for promoting disease …
specimens to identify the oncogenic signaling cascades responsible for promoting disease …
Blockade of redox second messengers inhibits JAK/STAT and MEK/ERK signaling sensitizing FLT3-mutant acute myeloid leukemia to targeted therapies
FLT3-mutations are diagnosed in 25-30% of patients with acute myeloid leukemia (AML)
and are associated with a poor prognosis. AML is associated with the overproduction of …
and are associated with a poor prognosis. AML is associated with the overproduction of …
PP2A activation targets AML stem cells
NM Verrills - Blood, The Journal of the American Society of …, 2022 - ashpublications.org
7. Kamdar M, Solomon Scott R, Arnason JE, et al. Lisocabtagene maraleucel (liso-cel), a
CD19-directed chimeric antigen receptor (CAR) T cell therapy, versus standard of care …
CD19-directed chimeric antigen receptor (CAR) T cell therapy, versus standard of care …
High-Throughput Global Phosphoproteomic Profiling Using Phospho Heavy-Labeled-Spiketide FAIMS Stepped-CV DDA (pHASED)
Global high-throughput profiling of oncogenic signaling pathways by phosphoproteomics is
increasingly being applied to cancer specimens. Such quantitative unbiased …
increasingly being applied to cancer specimens. Such quantitative unbiased …
[引用][C] Fibrinogen levels and thrombosis prevention
C Duval - Blood, The Journal of the American Society of …, 2022 - ashpublications.org
While PP2A activation has been proposed as a therapeutic option for a range of cancers
with inactivated PP2A, clinical trials have yet to eventuate. The demonstration that a …
with inactivated PP2A, clinical trials have yet to eventuate. The demonstration that a …