Genome-wide association studies (GWAS) have identified the PICALM (Phosphatidylinositol
binding clathrin-assembly protein) gene as the most significant genetic susceptibility locus …

Metabotropic glutamate receptor 5 (mGluR5) is ubiquitously expressed in brain regions
responsible for memory and learning. It plays a key role in modulating rapid changes in …

Alzheimer disease (AD) is the most prevalent type of dementia. It is marked by severe
memory loss and cognitive decline, and currently has limited effective treatment options …

The nitric oxide (NO)/cGMP pathway has been extensively studied for its pivotal role in
synaptic plasticity and memory processes, resulting in an increase of cAMP response …

Alzheimer's disease (AD) progressively inflicts impairment of synaptic functions with notable
deposition of amyloid-β (Aβ) as senile plaques within the extracellular space of the brain …

Exquisitely tuned activity of protein kinase C (PKC) isozymes is essential to maintaining
cellular homeostasis. Whereas loss-of-function mutations are generally associated with …

The synapse is the locus of plasticity where short-term alterations in synaptic strength are
converted to long-lasting memories. In addition to the presynaptic terminal and the …

The diagnosis of neurodegenerative disorders is often challenging due to the lack of
diagnostic tools, comorbidities and shared pathological manifestations. Synaptic dysfunction …

Peripheral sensory neurons located in dorsal root ganglia relay sensory information from the
peripheral tissue to the brain. Satellite glial cells (SGCs) are unique glial cells that form an …

The accumulation of amyloid-β protein (Aβ) plays an early role in the pathogenesis of
Alzheimer's disease (AD). The precise mechanism of how Aβ accumulation leads to synaptic …