TGF-β/Smad signaling pathway in tubulointerstitial fibrosis

XY Yu, Q Sun, YM Zhang, L Zou… - Frontiers in pharmacology, 2022 - frontiersin.org
Chronic kidney disease (CKD) was a major public health problem worldwide. Renal fibrosis,
especially tubulointerstitial fibrosis, is final manifestation of CKD. Many studies have …

Baicalin protects against renal interstitial fibrosis in mice by inhibiting the TGF-β/Smad signalling pathway

H Wang, Q Jiang, L Zhang - Pharmaceutical Biology, 2022 - Taylor & Francis
Context Baicalin, a flavonoid extracted from radix scutellariae, possesses various
pharmacological effects, including protective effects on renal interstitial fibrosis (RIF), but its …

[HTML][HTML] Shenkang injection protects against renal fibrosis by reducing perforin expression through the STING/TBK1/IRF3 signaling pathways in natural killer cells

J Hao, X Huang, J Guan, J Feng, D Li, S Cao, Y Li… - Phytomedicine, 2022 - Elsevier
Background Immune activation, chronic inflammation, and renal interstitial fibrosis (RIF) are
associated with chronic kidney disease (CKD). The herbal formula, Shenkang injection …

Natural products in regeneration

RB Wilson, JJ Lee, JG Pickering… - Regenerative …, 2022 - Elsevier
Renal damage can result from of a variety of insults, including exposure to nephrotoxins,
chronic illness, and acute conditions. During wound healing, macrophages infiltrate injured …

TGF-β Signaling: a Potential Therapeutic Target of Single Herbs and Extracts for Renal Fibrosis

G Huang, H Liang, Y Ma, Y Zhang - 2022 - researchsquare.com
Chronic kidney disease has emerged as a global public health problem in recent years.
Chronic kidney disease progression, characterized by the development of renal fibrosis …

Rehin Mitigates Chronic Kidney Injury by Decreasing the Release of Perforin and IFN-γ from Immune Cells Via Inhibiting the STING/TBK1/IRF3 Pathway Activation

J Wang, X Huang, Y Liao, X Cai, J Xu, J Hao, C Zhu - 2022 - researchsquare.com
Shenkang suppository (SKS), a Chinese medicinal preparation rich in various natural
ingredients, has not been reported in any studies related to fibrosis. Our experiments …