Mini review: The role of sensory innervation to subchondral bone in osteoarthritis pain

M Morgan, V Nazemian, K Harrington… - Frontiers in …, 2022 - frontiersin.org
Osteoarthritis pain is often thought of as a pain driven by nerves that innervate the soft
tissues of the joint, but there is emerging evidence for a role for nerves that innervate the …

[HTML][HTML] The challenges of treating osteoarthritis pain and opportunities for novel peripherally directed therapeutic strategies

S Gonçalves, PRW Gowler, SG Woodhams… - …, 2022 - Elsevier
Osteoarthritis (OA) is a chronic joint disease that represents an increasingly substantial
global burden. Joint pain is the most significant symptom of OA. Unfortunately, current …

Changes to the activity and sensitivity of nerves innervating subchondral bone contribute to pain in late-stage osteoarthritis

M Morgan, J Thai, V Nazemian, R Song, JJ Ivanusic - Pain, 2022 - journals.lww.com
Although it is clear that osteoarthritis (OA) pain involves activation and/or sensitization of
nociceptors that innervate knee joint articular tissues, much less is known about the role of …

[HTML][HTML] Rodent models of knee osteoarthritis for pain research

M Alves-Simões - Osteoarthritis and Cartilage, 2022 - Elsevier
Osteoarthritis (OA) is a chronic degenerative joint disease and a leading cause of disability
worldwide. Pain is the main symptom, yet no current treatment can halt disease progression …

Chronic pain causes peripheral and central responses in MIA-induced TMJOA rats

H Jiang, L Xu, W Liu, M Xiao, J Ke, X Long - Cellular and molecular …, 2022 - Springer
Chronic pain is the predominant symptom that drives temporomandibular joint osteoarthritis
(TMJOA) patients to seek medical care; however, currently used treatment modalities remain …

[HTML][HTML] Protective effect of a novel polyherbal formulation on experimentally induced osteoarthritis in a rat model

C Orhan, M Tuzcu, AS Durmus, N Sahin… - Biomedicine & …, 2022 - Elsevier
Osteoarthritis (OA) is a musculoskeletal disorder mainly found in elderly individuals. Modern
treatment of OA, like nonsteroidal anti-inflammatory drugs, corticosteroids, hyaluronic acid …

Investigating the role of artemin and its cognate receptor, GFRα3, in osteoarthritis pain

L Minnema, A Gupta, SK Mishra… - Frontiers in …, 2022 - frontiersin.org
Osteoarthritis (OA) associated pain (OA-pain) is a significant global problem. OA-pain limits
limb use and mobility and is associated with widespread sensitivity. Therapeutic options are …

Spinal 5-HT2A receptor is involved in electroacupuncture inhibition of chronic pain

XC Yuan, YY Wang, LX Tian, XJ Yan, YX Guo… - Molecular …, 2022 - journals.sagepub.com
Knee osteoarthritis (KOA) is a highly prevalent, chronic joint disorder, and it is a typical
disease which can develop chronic pain. Our previous study has proved that …

Fire needling acupuncture suppresses cartilage damage by mediating macrophage polarization in mice with knee osteoarthritis

J Wei, L Liu, Z Li, T Lyu, L Zhao, X Xu… - Journal of Pain …, 2022 - Taylor & Francis
Purpose Macrophage polarization contributes to the mechanisms of treating knee
osteoarthritis (KOA). In previous studies, fire needling acupuncture has been shown to affect …

[HTML][HTML] Pathological, morphometric and correlation analysis of the modified mankin score, tidemark roughness and calcified cartilage thickness in rat knee …

JH Cheng, WY Chou, CJ Wang, KK Siu… - … Journal of Medical …, 2022 - ncbi.nlm.nih.gov
The paper displayed the pathological changes and relationships of the modified Mankin
score, tidemark roughness and calcified cartilage (CC) thickness by extracorporeal …