[HTML][HTML] An overview of vaccine adjuvants: current evidence and future perspectives
Vaccinations are one of the most important preventive tools against infectious diseases.
Over time, many different types of vaccines have been developed concerning the antigen …
Over time, many different types of vaccines have been developed concerning the antigen …
Engineered nanomaterials for synergistic photo-immunotherapy
R Guo, S Wang, L Zhao, Q Zong, T Li, G Ling, P Zhang - Biomaterials, 2022 - Elsevier
Nanomaterial-synergized photodynamic therapy (PDT) and photothermal therapy (PTT), as
efficient and non-invasive treatment modalities, have shown significant advantages in …
efficient and non-invasive treatment modalities, have shown significant advantages in …
[HTML][HTML] Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine
Despite the success of the BNT162b2 mRNA vaccine, the immunological mechanisms that
underlie its efficacy are poorly understood. Here we analyzed the innate and adaptive …
underlie its efficacy are poorly understood. Here we analyzed the innate and adaptive …
[HTML][HTML] The battle between host and SARS-CoV-2: Innate immunity and viral evasion strategies
The SARS-CoV-2 virus, the pathogen causing COVID-19, has caused more than 200 million
confirmed cases, resulting in more than 4.5 million deaths worldwide by the end of August …
confirmed cases, resulting in more than 4.5 million deaths worldwide by the end of August …
Human enteric viruses autonomously shape inflammatory bowel disease phenotype through divergent innate immunomodulation
F Adiliaghdam, H Amatullah, S Digumarthi… - Science …, 2022 - science.org
Altered enteric microorganisms in concert with host genetics shape inflammatory bowel
disease (IBD) phenotypes. However, insight is limited to bacteria and fungi. We found that …
disease (IBD) phenotypes. However, insight is limited to bacteria and fungi. We found that …
[HTML][HTML] African swine fever virus I267L acts as an important virulence factor by inhibiting RNA polymerase III-RIG-I-mediated innate immunity
Y Ran, D Li, MG Xiong, HN Liu, T Feng, ZW Shi… - PLoS …, 2022 - journals.plos.org
ASFV is a large DNA virus that is highly pathogenic in domestic pigs. How this virus is
sensed by the innate immune system as well as why it is so virulent remains enigmatic. In …
sensed by the innate immune system as well as why it is so virulent remains enigmatic. In …
[HTML][HTML] SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA
S Maharana, S Kretschmer, S Hunger, X Yan, D Kuster… - Molecular cell, 2022 - cell.com
Recognition of pathogen-derived foreign nucleic acids is central to innate immune defense.
This requires discrimination between structurally highly similar self and nonself nucleic acids …
This requires discrimination between structurally highly similar self and nonself nucleic acids …
[HTML][HTML] TLR3 controls constitutive IFN-β antiviral immunity in human fibroblasts and cortical neurons
Human herpes simplex virus 1 (HSV-1) encephalitis can be caused by inborn errors of the
TLR3 pathway, resulting in impairment of CNS cell-intrinsic antiviral immunity. Deficiencies …
TLR3 pathway, resulting in impairment of CNS cell-intrinsic antiviral immunity. Deficiencies …
Actin cytoskeleton remodeling primes RIG-I-like receptor activation
The current dogma of RNA-mediated innate immunity is that sensing of immunostimulatory
RNA ligands is sufficient for the activation of intracellular sensors and induction of interferon …
RNA ligands is sufficient for the activation of intracellular sensors and induction of interferon …
Robust delivery of RIG‐I agonists using extracellular vesicles for anti‐cancer immunotherapy
The RIG‐I pathway can be activated by RNA containing 5′ triphosphate, leading to type I
interferon release and immune activation. Hence, RIG‐I agonists have been used to induce …
interferon release and immune activation. Hence, RIG‐I agonists have been used to induce …