[HTML][HTML] Tracing the origin of cell-Free DNA molecules through tissue-Specific epigenetic signatures
All cell and tissue types constantly release DNA fragments into human body fluids by various
mechanisms including programmed cell death, accidental cell degradation and active …
mechanisms including programmed cell death, accidental cell degradation and active …
[HTML][HTML] Computational challenges in detection of cancer using cell-free DNA methylation
Cell-free DNA (cfDNA) methylation profiling is considered promising and potentially reliable
for liquid biopsy to study progress of diseases and develop reliable and consistent …
for liquid biopsy to study progress of diseases and develop reliable and consistent …
[HTML][HTML] Methylation risk scores are associated with a collection of phenotypes within electronic health record systems
Inference of clinical phenotypes is a fundamental task in precision medicine, and has
therefore been heavily investigated in recent years in the context of electronic health records …
therefore been heavily investigated in recent years in the context of electronic health records …
[HTML][HTML] Genome-wide placental gene methylations in gestational diabetes mellitus, fetal growth and metabolic health biomarkers in cord blood
WJ Wang, R Huang, T Zheng, Q Du, MN Yang… - Frontiers in …, 2022 - frontiersin.org
Gestational diabetes mellitus (GDM)“program” an elevated risk of metabolic syndrome in the
offspring. Epigenetic alterations are a suspected mechanism. GDM has been associated …
offspring. Epigenetic alterations are a suspected mechanism. GDM has been associated …
Associations between infant sex and DNA methylation across umbilical cord blood, artery, and placenta samples
ABSTRACT DNA methylation (DNAm) is vulnerable to dysregulation by environmental
exposures during epigenetic reprogramming that occurs in embryogenesis. Sexual …
exposures during epigenetic reprogramming that occurs in embryogenesis. Sexual …
[HTML][HTML] Epigenome-wide association study of lung function in Latino children and youth with asthma
Introduction DNA methylation studies have associated methylation levels at different CpG
sites or genomic regions with lung function. Moreover, genetic ancestry has been associated …
sites or genomic regions with lung function. Moreover, genetic ancestry has been associated …
[HTML][HTML] Investigation of measurable residual disease in acute myeloid leukemia by DNA methylation patterns
Assessment of measurable residual disease (MRD) upon treatment of acute myeloid
leukemia (AML) remains challenging. It is usually addressed by highly sensitive PCR-or …
leukemia (AML) remains challenging. It is usually addressed by highly sensitive PCR-or …
[HTML][HTML] DNA Methylation-based prediction of post-operative atrial fibrillation
MA Fischer, A Mahajan, M Cabaj, TH Kimball… - Frontiers in …, 2022 - frontiersin.org
Background Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and post-
operative atrial fibrillation (POAF) is a major healthcare burden, contributing to an increased …
operative atrial fibrillation (POAF) is a major healthcare burden, contributing to an increased …
[HTML][HTML] Risk subtyping and prognostic assessment of prostate cancer based on consensus genes
J Meng, Y Guan, B Wang, L Chen, J Chen… - Communications …, 2022 - nature.com
Prostate cancer (PCa) is the most frequent malignancy in male urogenital system around
worldwide. We performed molecular subtyping and prognostic assessment based on …
worldwide. We performed molecular subtyping and prognostic assessment based on …
[HTML][HTML] DNA methylation changes in cord blood and the developmental origins of health and disease–a systematic review and replication study
Background Environmental exposures in utero which modify DNA methylation may have a
long-lasting impact on health and disease in offspring. We aimed to identify and replicate …
long-lasting impact on health and disease in offspring. We aimed to identify and replicate …