Modelling the neurodevelopmental pathogenesis in neuropsychiatric disorders. Bioactive kynurenines and their analogues as neuroprotective agents—In celebration …
M Tanaka, E Spekker, Á Szabó, H Polyák… - Journal of Neural …, 2022 - Springer
Following introduction of the monoamine oxidase type B inhibitor selegiline for the treatment
of Parkinson's disease (PD), discovery of the action mechanism of Alzheimer's disease …
of Parkinson's disease (PD), discovery of the action mechanism of Alzheimer's disease …
RhoA signaling in neurodegenerative diseases
Ras homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in
regulating multiple signal transduction pathways that influence a diverse range of cellular …
regulating multiple signal transduction pathways that influence a diverse range of cellular …
Emerging evidence for astrocyte dysfunction in schizophrenia
Schizophrenia is a complex, chronic mental health disorder whose heterogeneous genetic
and neurobiological background influences early brain development, and whose precise …
and neurobiological background influences early brain development, and whose precise …
The prediction-error hypothesis of schizophrenia: new data point to circuit-specific changes in dopamine activity
Schizophrenia is a severe psychiatric disorder affecting 21 million people worldwide. People
with schizophrenia suffer from symptoms including psychosis and delusions, apathy …
with schizophrenia suffer from symptoms including psychosis and delusions, apathy …
An in vitro model of neuronal ensembles
Advances in 3D neuronal cultures, such as brain spheroids and organoids, are allowing
unprecedented in vitro access to some of the molecular, cellular and developmental …
unprecedented in vitro access to some of the molecular, cellular and developmental …
Loss of schizophrenia-related miR-501-3p in mice impairs sociability and memory by enhancing mGluR5-mediated glutamatergic transmission
W Liang, Y Hou, W Huang, Y Wang, T Jiang… - Science …, 2022 - science.org
Schizophrenia is a polygenetic disease, the heterogeneity of which is likely complicated by
epigenetic modifications yet to be elucidated. Here, we performed transcriptomic analysis of …
epigenetic modifications yet to be elucidated. Here, we performed transcriptomic analysis of …
The 22q11. 2 region regulates presynaptic gene-products linked to schizophrenia
R Nehme, O Pietiläinen, M Artomov… - Nature …, 2022 - nature.com
It is unclear how the 22q11. 2 deletion predisposes to psychiatric disease. To study this, we
generated induced pluripotent stem cells from deletion carriers and controls and utilized …
generated induced pluripotent stem cells from deletion carriers and controls and utilized …
Autoinflammatory keratinization disease with hepatitis and autism reveals roles for JAK1 kinase hyperactivity in autoinflammation
T Takeichi, JYW Lee, Y Okuno, Y Miyasaka… - Frontiers in …, 2022 - frontiersin.org
Heterozygous mutations in JAK1 which result in JAK-STAT hyperactivity have been
implicated in an autosomal dominant disorder that features multi-organ immune …
implicated in an autosomal dominant disorder that features multi-organ immune …
Craniofacial phenotypes and genetics of DiGeorge syndrome
N Funato - Journal of Developmental Biology, 2022 - mdpi.com
The 22q11. 2 deletion is one of the most common genetic microdeletions, affecting
approximately 1 in 4000 live births in humans. A 1.5 to 2.5 Mb hemizygous deletion of …
approximately 1 in 4000 live births in humans. A 1.5 to 2.5 Mb hemizygous deletion of …
Mapping miRNA Research in Schizophrenia: a scientometric review
Micro RNA (miRNA) research has great implications in uncovering the aetiology of
neuropsychiatric conditions due to the role of miRNA in brain development and function …
neuropsychiatric conditions due to the role of miRNA in brain development and function …