Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …

The accumulation of an excessive amount of body fat can cause type 2 diabetes, and the
risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly …

Obesity remains the most important risk factor for the incidence and progression of
osteoarthritis (OA). The leading cause of OA was believed to be overloading the joints due to …

Obesity usually is accompanied by inflammation of fat tissue, with a prominent role of
visceral fat. Chronic inflammation in obese fat tissue is of a lower grade than acute immune …

Abstract Background Adipose tissue macrophages (ATMs) are a well characterized
regulator of adipose tissue inflammatory tone. Previously defined by the M1 vs M2 …

Inflammation plays a decisive role in inducing tumorigenesis, promoting tumor development,
tumor invasion and migration. The interaction of cancer cells with their surrounding stromal …

Abstract Purpose of Review Obesity has increased worldwide recently and represents a
major global health challenge. This review focuses on the obesity-associated cellular …

Lifestyle therapy (energy restriction and exercise) is the cornerstone of therapy for people
with type 2 diabetes (T2D) but is difficult to implement. We conducted an 8-month …

Tissue-resident memory (TRM) T cells are a unique subset of memory T cells that are critical
for the first line of defense against pathogens or antigens in peripheral non-lymphoid tissues …

Abstract Purpose of Review Anti-hypertensive and lipid lowering therapy addresses only
half of the cardiovascular disease risk in patients with body mass index> 30 kg/m2, ie …