Desmin is the primary intermediate filament (IF) of cardiac, skeletal, and smooth muscle. By
linking the contractile myofibrils to the sarcolemma and cellular organelles, desmin IF …

During postnatal cardiac development, cardiomyocytes mature and turn into adult ones.
Hence, all cellular properties, including morphology, structure, physiology and metabolism …

Desmin mutations cause familial and sporadic cardiomyopathies. In addition to perturbing
the contractile apparatus, both desmin deficiency and mutated desmin negatively impact …

Mitochondria are cell organelles that play pivotal roles in maintaining cell survival, cellular
metabolic homeostasis, and cell death. Mitochondria are highly dynamic entities which …

Analysis of the function, structure, and intracellular organization of mitochondria is important
for elucidating energy metabolism and intracellular energy transfer. In addition, basic and …

Mitochondria are ubiquitous organelles that play a pivotal role in the supply of energy
through the production of adenosine triphosphate in all eukaryotic cells. The importance of …

Impairments in macroautophagy/autophagy, which degrades dysfunctional organelles as
well as long-lived and aggregate proteins, are associated with several cardiomyopathies; …

Due to the fact that statins are among the most high-demand therapeutic agents used for the
treatment and prevention of the most common cardiovascular diseases, a significant amount …

The heart's limited regenerative capacity raises the need for novel stem cell-based
therapeutic approaches for cardiac regeneration. However, the use of stem cells is restrictive …

ABSTRACT X-linked myotubular myopathy (XLMTM) is a severe monogenetic disorder of
the skeletal muscle. It is caused by loss-of-expression/function mutations in the myotubularin …