Autophagy is a highly conserved catabolic process cells use to maintain their homeostasis
by degrading misfolded, damaged and excessive proteins, nonfunctional organelles, foreign …

Background With long-term metabolic malfunction, diabetes can cause serious damage to
whole-body tissue and organs, resulting in a variety of complications. Therefore, it is …

Endometriosis (EMs) occurs in approximately 50% of women with infertility. The main
causes of EMs-related infertility are follicle dysplasia and reduced oocyte quality. Iron …

Ferroptosis is a newly recognized form of regulated cell death that is characterized by
severe lipid peroxidation initiated by iron overload and the generation of reactive oxygen …

Pancreatic ductal adenocarcinomas (PDAC) depend on autophagy for survival; however,
the metabolic substrates that autophagy provides to drive PDAC progression are unclear …

Background SARS-CoV-2 infection causes acute respiratory distress, which may progress to
multiorgan failure and death. Severe COVID-19 disease is accompanied by reduced …

A ferritin particle consists of 24 ferritin proteins (FTH1 and FTL) and stores iron ions within it.
During iron deficiency, ferritin particles are transported to lysosomes to release iron ions …

Ischemia-reperfusion (I/R) injury is a major challenge in perioperative medicine that
contributes to pathological damage in various conditions, including ischemic stroke …

Alzheimer's disease (AD) accounts for two-thirds of all dementia cases, affecting 50 million
people worldwide. Only four of the more than 100 AD drugs developed thus far have …

TP53 mutations correlate with inferior survival in many cancers. APR-246 is a compound to
shift mutant p53 and exhibits anti-cancer effects. Among its effects, APR-246 facilitates the …