The neural basis of psychedelic action
Psychedelics are serotonin 2A receptor agonists that can lead to profound changes in
perception, cognition and mood. In this review, we focus on the basic neurobiology …
perception, cognition and mood. In this review, we focus on the basic neurobiology …
Psychedelics, mystical experience, and therapeutic efficacy: A systematic review
The mystical experience is a potential psychological mechanism to influence outcome in
psychedelic therapy. It includes features such as oceanic boundlessness, ego dissolution …
psychedelic therapy. It includes features such as oceanic boundlessness, ego dissolution …
Single-dose psilocybin for a treatment-resistant episode of major depression
GM Goodwin, ST Aaronson, O Alvarez… - … England Journal of …, 2022 - Mass Medical Soc
Background Psilocybin is being studied for use in treatment-resistant depression. Methods
In this phase 2 double-blind trial, we randomly assigned adults with treatment-resistant …
In this phase 2 double-blind trial, we randomly assigned adults with treatment-resistant …
Percentage of heavy drinking days following psilocybin-assisted psychotherapy vs placebo in the treatment of adult patients with alcohol use disorder: a randomized …
MP Bogenschutz, S Ross, S Bhatt, T Baron… - JAMA …, 2022 - jamanetwork.com
Importance Although classic psychedelic medications have shown promise in the treatment
of alcohol use disorder (AUD), the efficacy of psilocybin remains unknown. Objective To …
of alcohol use disorder (AUD), the efficacy of psilocybin remains unknown. Objective To …
Efficacy and safety of psilocybin-assisted treatment for major depressive disorder: Prospective 12-month follow-up
Background: Preliminary data suggest that psilocybin-assisted treatment produces
substantial and rapid antidepressant effects in patients with major depressive disorder …
substantial and rapid antidepressant effects in patients with major depressive disorder …
Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity
There is considerable interest in screening ultralarge chemical libraries for ligand discovery,
both empirically and computationally,,–. Efforts have focused on readily synthesizable …
both empirically and computationally,,–. Efforts have focused on readily synthesizable …
The promises and perils of psychedelic pharmacology for psychiatry
TD McClure-Begley, BL Roth - Nature Reviews Drug Discovery, 2022 - nature.com
Psychedelic drugs including psilocybin, N, N ʹ-dimethyltryptamine (DMT) and lysergic acid
diethylamide (LSD) are undergoing a renaissance as potentially useful drugs for various …
diethylamide (LSD) are undergoing a renaissance as potentially useful drugs for various …
Structure-based discovery of nonhallucinogenic psychedelic analogs
D Cao, J Yu, H Wang, Z Luo, X Liu, L He, J Qi, L Fan… - Science, 2022 - science.org
Drugs that target the human serotonin 2A receptor (5-HT2AR) are used to treat
neuropsychiatric diseases; however, many have hallucinogenic effects, hampering their use …
neuropsychiatric diseases; however, many have hallucinogenic effects, hampering their use …
Adverse effects of psychedelics: From anecdotes and misinformation to systematic science
Background: Despite an increasing body of research highlighting their efficacy to treat a
broad range of medical conditions, psychedelic drugs remain a controversial issue among …
broad range of medical conditions, psychedelic drugs remain a controversial issue among …
[HTML][HTML] Pharmacological, neural, and psychological mechanisms underlying psychedelics: A critical review
This paper provides a critical review of several possible mechanisms at different levels of
analysis underlying the effects and therapeutic potential of psychedelics. At the (1) …
analysis underlying the effects and therapeutic potential of psychedelics. At the (1) …