Beyond the approved: target sites and inhibitors of bacterial RNA polymerase from bacteria and fungi

SH Kirsch, FPJ Haeckl, R Müller - Natural Product Reports, 2022 - pubs.rsc.org
Covering: 2016 to 2022 RNA polymerase (RNAP) is the central enzyme in bacterial gene
expression representing an attractive and validated target for antibiotics. Two well-known …

The Alternative Sigma Factor SigL Influences Clostridioides difficile Toxin Production, Sporulation, and Cell Surface Properties

AE Clark, CC Adamson, KE Carothers… - Frontiers in …, 2022 - frontiersin.org
The alternative sigma factor SigL (Sigma-54) facilitates bacterial adaptation to the
extracellular environment by modulating the expression of defined gene subsets. A homolog …

Identification and Characterization of the Alternative σ28 Factor in Treponema denticola

K Kurniyati, Y Chang, J Liu, C Li - Journal of Bacteriology, 2022 - Am Soc Microbiol
FliA (also known as σ28), a member of the bacterial σ70 family of transcription factors,
directs RNA polymerase to flagellar late (class 3) promoters and initiates transcription. FliA …

Investigating RNA polymerase regulation in antibiotic producing streptomyces bacteria

H Greenfield - 2022 - sussex.figshare.com
Organisms belonging to the Streptomyces genus produce a vast number of useful
secondary metabolites, including over half of all clinically relevant antibiotics. Recent …

[HTML][HTML] Fluoreszenzbasierte Systeme zum Nachweis der Produktion und Sekretion von Proteinen in Bacillus subtilis

P Lenz - docserv.uni-duesseldorf.de
Beschreibungen: Das Gram-positive Bakterium Bacillus subtilis ist ein gut etablierter Wirt,
der in biotechnologischen Produktionsprozessen für die Synthese und Sekretion von …