Signal transducer and activator of transcription (STAT) proteins are latent transcription
factors that reside in the cytoplasm of several types of cells. In canonical signaling, upon …

The endoplasmic reticulum is the most abundant membrane organelle in eukaryotic cells. It
is an important site of membrane and secretory protein folding and glycolipid synthesis and …

In this work, site-selective C–H activation at C-5, C-3 and C-2 positions of chromones for the
introduction of structural diversity to the chromone scaffold was studied. The keto group of …

Among all cancers, hepatocellular carcinoma (HCC) remains a lethal disease with limited
treatment options. In this study, we have analyzed the possible inhibitory effects of …

Vernonia glaberrima leaves are traditionally used to alleviate bodily pain, skin cancer, and
other skin-related disorders. The purpose of the study was to investigate the acute and sub …

A number of uracil amides cleave poly (ADP-ribose) polymerase and therefore novel
thiouracil amide compounds were synthesized and screened for the loss of cell viability in a …

This paper highlights the notable bioactivity and pharmaceutical significance of the natural
furocoumarin viz. Bergapten (BG), extracted from the medicinal plant Melicopedenhamii …

4-Bromoacetyl pyridine 2a and 3-bromoacetylcoumarine 2b react with malononitrile 3 and
thiourea 6 to afford the furan and the thiazole derivatives 5a, b and 7a, b respectively. The …

Cystic fibrosis (CF) is a monogenetic disease caused mostly by the F508del mutation, a
deletion of phenylalanine at position 508 of the CF transmembrane conductance regulator …