Perioperative hypotension has been repeatedly associated with organ injury and worse
outcome, yet many interventions to reduce morbidity by attempting to avoid or reverse …

Background Liver hepatocellular carcinoma (LIHC) ranks sixth among the most common
types of cancer with a high mortality rate. Cuproptosis is a newly discovered type of cell …

Cancer metastasis and treatment resistance are the main causes of treatment failure and
cancer-related deaths. Their underlying mechanisms remain to be fully elucidated and have …

Background Preclinical studies indicate that the concurrent use of inhibitors of the renin–
angiotensin–aldosterone system (RAAS) may improve outcomes in broad groups of patients …

Purpose: There is increasing recognition that progress in immuno-oncology could be
accelerated by evaluating immune-based therapies in dogs with spontaneous cancers …

G protein‐coupled receptors (GPCRs) are the most common and important drug targets.
However,> 70% of GPCRs are undruggable or difficult to target using conventional chemical …

Non-communicable diseases, like diabetes, cardiovascular diseases, cancer, stroke, chronic
obstructive pulmonary disease, osteoporosis, arthritis, Alzheimer's disease and other more …

Immunotherapies modulate the function of immune cells to eradicate cancer cells through
various mechanisms. These therapies are successful across a spectrum of cancers, but they …

Background Overexpression of the angiotensin-II receptor and renin–angiotensin system
(RAS) has been reported in several malignancies, including colorectal-cancer (CRC) …

Hypertension is the most prevalent comorbidity in cancer patients. Consequently, many
cancer patients are prescribed antihypertensive drugs before cancer diagnosis or during …