[HTML][HTML] The tumor microenvironment of hepatocellular carcinoma: untying an intricate immunological network

C Volponi, A Gazzillo, E Bonavita - Cancers, 2022 - mdpi.com
Simple Summary In this review, we analyze the contribution of the most abundant immune
cell populations in hepatocellular carcinoma (HCC) progression and response to therapy …

Dysfunctional state of T cells or exhaustion during chronic viral infections and COVID-19: a review

KP Mishra, M Singh, D Saraswat, L Ganju… - Viral …, 2022 - liebertpub.com
Coronavirus disease 2019 (COVID-19) continuously affecting the lives of millions of people.
The virus is spread through the respiratory route to an uninfected person, causing mild-to …

[HTML][HTML] Serum neutralization activity declines but memory B cells persist after cure of chronic hepatitis C

A Nishio, S Hasan, H Park, N Park, JH Salas… - Nature …, 2022 - nature.com
The increasing incidence of hepatitis C virus (HCV) infections underscores the need for an
effective vaccine. Successful vaccines to other viruses generally depend on a long-lasting …

Innate‐like bystander‐activated CD38+HLA‐DR+CD8+T cells play a pathogenic role in patients with chronic hepatitis C

CH Huang, JH Fan, WJ Jeng, ST Chang, CK Yang… - …, 2022 - Wiley Online Library
Background and Aims HCV‐specific T cells are few and exhausted in patients with chronic
hepatitis C (CHC). Whether these T cells are responsible for the liver damage and fibrosis is …

[HTML][HTML] Soluble Immune checkpoint protein CD27 is a Novel Prognostic Biomarker of Hepatocellular Carcinoma Development in Hepatitis C virus–sustained …

MP Dong, DV Hoang, H Hai, TH Hoang… - The American Journal of …, 2022 - Elsevier
Factors affecting the probability of hepatocellular carcinoma (HCC) development even after
sustained virological response (SVR) following anti–hepatitis C virus (HCV) therapy remain …

[HTML][HTML] The IL6-174G/C Polymorphism Associated with High Levels of IL-6 Contributes to HCV Infection, but Is Not Related to HBV Infection, in the Amazon Region of …

MAF Queiroz, AM Santiago, TCF Moura, ESG Amoras… - Viruses, 2022 - mdpi.com
The dysregulation of cytokine production can lead to an inefficient immune response,
promoting viral persistence that induces the progression of chronic viral hepatitis. The study …

[HTML][HTML] The knowledge on HCV: from the discovery to the elimination

J Guan, Y Ren, J Wang, H Zhu - Infectious Microbes & Diseases, 2022 - journals.lww.com
From being described as “non-A, non-B” hepatitis in 1975 and being identified in 1989, to
the emergence of direct-acting antiviral drugs (DAAs), knowledge on hepatitis C virus (HCV) …

T cell subsets in chronic hepatitis C patients genotype 4 who achieved SVR following DAAs Therapy

G Shiha, R Soliman, AA Hassan, NNH Mikhail, A Nabil… - bioRxiv, 2022 - biorxiv.org
Background T cells are the primary effector cells that mediate viral clearance in spontaneous
recovery from HCV infection and T cell dysfunction is a hallmark of progression to chronic …

Intrahepatic immune infiltrate in chronic hepatitis B and chronic hepatitis C: Similar but not the same

CG Giadans, DA Ríos, B Ameigeiras… - Journal of Viral …, 2022 - Wiley Online Library
In chronic hepatitis B (CHB) and C (CHC) infections, the composition of the immune cell
microenvironment at the site of infection is poorly understood. Thus, our aim was to …

Suivi de la réponse immunitaire adaptative spécifique d'un antigène exprimé dans le foie

A Cardon - 2022 - theses.hal.science
Le foie présente des capacités de tolérance particulières. Celles-ci peuvent être altérées et
conduire au développement de maladies auto-immunes hépatiques telles que l'hépatite …