NF-kB activation in canine cancer
LJ Schlein, DH Thamm - Veterinary pathology, 2022 - journals.sagepub.com
Spontaneous tumors in dogs share several environmental, epidemiologic, biologic, clinical
and molecular features with a wide variety of human cancers, making this companion animal …
and molecular features with a wide variety of human cancers, making this companion animal …
The role of telomerase in breast Cancer's response to Therapy
E Judasz, N Lisiak, P Kopczyński, M Taube… - International journal of …, 2022 - mdpi.com
Currently, breast cancer appears to be the most widespread cancer in the world and the
most common cause of cancer deaths. This specific type of cancer affects women in both …
most common cause of cancer deaths. This specific type of cancer affects women in both …
Ligand-based design on the dog-bone-shaped BIBR1532 pharmacophoric features and synthesis of novel analogues as promising telomerase inhibitors with in vitro …
Telomerase is an outstanding biological target for cancer treatment. BIBR1532 is a non-
nucleoside selective telomerase inhibitor; however, it experiences ineligible …
nucleoside selective telomerase inhibitor; however, it experiences ineligible …
Oncolytic adenovirus promotes vascular normalization and nonclassical tertiary lymphoid structure formation through STING-mediated DC activation
T He, Z Hao, M Lin, Z Xin, Y Chen, W Ouyang… - …, 2022 - Taylor & Francis
Inducing a full antitumor immune response in the tumor microenvironment (TME) is essential
for successful cancer immunotherapy. Here, we report that an oncolytic adenovirus carrying …
for successful cancer immunotherapy. Here, we report that an oncolytic adenovirus carrying …
New genetic bomb trigger: Design, synthesis, molecular dynamics simulation, and biological evaluation of novel BIBR1532-related analogs targeting telomerase …
Telomeres serve a critical function in cell replication and proliferation at every stage of the
cell cycle. Telomerase is a ribonucleoprotein, responsible for maintaining the telomere …
cell cycle. Telomerase is a ribonucleoprotein, responsible for maintaining the telomere …
Telomere therapy for chronic kidney disease
OA Akinnibosun, MC Maier, J Eales… - …, 2022 - Taylor & Francis
Chronic kidney disease (CKD) is estimated to affect almost 10% of individuals worldwide
and is one of the leading causes of morbidity and mortality. Renal fibrosis, a central pathway …
and is one of the leading causes of morbidity and mortality. Renal fibrosis, a central pathway …
Targeting visualization of malignant tumor based on the alteration of DWI signal generated by hTERT promoter–driven AQP1 overexpression
L Zhang, M Gong, S Lei, C Cui, Y Liu, S Xiao… - European Journal of …, 2022 - Springer
Purpose To specifically diagnose malignant tumors in DWI using the human telomerase
reverse transcriptase (hTERT) promoter–driven AQP1 expression. Methods The human …
reverse transcriptase (hTERT) promoter–driven AQP1 expression. Methods The human …
Detection of acquired TERT amplification in addition to predisposing p53 and Rb pathways alterations in EGFR-mutant lung adenocarcinomas transformed into small …
A Mc Leer, M Foll, M Brevet, M Antoine, S Novello… - Lung Cancer, 2022 - Elsevier
Introduction Among the different mechanisms of acquired resistance to EGFR tyrosine
kinase inhibitors (TKIs) reported in EGFR-mutated lung adenocarcinoma (EGFR-LUAD) …
kinase inhibitors (TKIs) reported in EGFR-mutated lung adenocarcinoma (EGFR-LUAD) …
Targeting telomerase reverse transcriptase with the covalent inhibitor NU-1 confers immunogenic radiation sensitization
Beyond synthesizing telomere repeats, the telomerase reverse transcriptase (TERT) also
serves multiple other roles supporting cancer growth. Blocking telomerase to drive telomere …
serves multiple other roles supporting cancer growth. Blocking telomerase to drive telomere …
MAPK/ERK‐CBP‐RFPL‐3 Mediates Adipose‐Derived Stem Cell‐Induced Tumor Growth in Breast Cancer Cells by Activating Telomerase Reverse Transcriptase …
W Li, C Qian, F Ma, M Liu, X Sun, X Liu… - Stem Cells …, 2022 - Wiley Online Library
Adipose‐derived stem cells (ASCs) improve the self‐renewal and survival of fat grafts in
breast reconstruction after oncology surgery. However, ASCs have also been found to …
breast reconstruction after oncology surgery. However, ASCs have also been found to …