Metabolic reprogramming is one of the main characteristics of malignant tumors. The
metabolic reprogramming of tumors is not only related to the characteristics of cancer cells …

Metabolic reprogramming is one of the main hallmarks of cancer cells. It refers to the
metabolic adaptations of tumor cells in response to nutrient deficiency, microenvironmental …

There is an urgent need for exploring new actionable targets other than androgen receptor
to improve outcome from lethal castration-resistant prostate cancer. Tumor metabolism has …

We report the design and synthesis of fifteen novel ferrocene-based triazolopyrimidines and
several other studies that establish these molecules as PKM2 modulators. Our ferrocene …

Prostate cancer (PC), the fifth leading cause of cancer-related mortality worldwide, is known
as metastatic bone cancer when it spreads to the bone. Although there is still no effective …

Abstract Background Pyruvate kinase M2 (PKM2) is preferentially expressed as a low-
activity dimer over the active tetramer in proliferating tumor cells, resulting in metabolic …

Abstract prevalence was reported as 1: 3000-4000 worldwide, making it the main reason for
blindness in the working population in industrial countries. The mutations of over 70 genes …