Ovarian cancer has the highest mortality of all of the gynecological malignancies. There are
several distinct histotypes of this malignancy characterized by specific molecular events and …

Simple Summary It was found that long-established tumor-derived cell lines do not
adequately reproduce drug sensitivity and behavior of a real human cancers. Therefore …

Drug discovery is an expensive and lengthy process. Among the different phases, drug
discovery and preclinical trials play an important role as only 5–10 of all drugs that begin …

Background Gamma delta (γδ) T lymphocytes are promising candidate for adoptive T cell
therapy, however, their treatment efficacy is not satisfactory. Vδ2 T cells are unique to …

In biomaterials R&D, conventional monolayer cell culture on flat/planar material samples,
such as films, is still commonly employed at early stages of the assessment of interactions of …

Cell encapsulation within the microspheres using a semi-permeable polymer allows the two-
way transfer of molecules such as oxygen, nutrients, and growth factors. The main …

Spaceflight affects the body on every level. Reports on astronaut health identify bone
marrow remodelling and dysfunction of the innate immune system as significant health risks …

Traditional studies using cancer cell lines are often performed on a two-dimensional (2D)
cell culture model with a low success rate of translating to Phase I or Phase II clinical …

Metastatic cancers can be highly heterogeneous, show large patient variability and are
typically hard to treat due to chemoresistance. Personalized therapies are therefore needed …

The purpose of the present study was to evaluate the effects of vascular endothelial growth
factor (VEGF) on tumorigenic properties in two‑dimensional (2D) and three‑dimensional …