Adipose-tissue plasticity in health and disease
Adipose tissue, colloquially known as" fat," is an extraordinarily flexible and heterogeneous
organ. While historically viewed as a passive site for energy storage, we now appreciate that …
organ. While historically viewed as a passive site for energy storage, we now appreciate that …
Browning of the white adipose tissue regulation: New insights into nutritional and metabolic relevance in health and diseases
SA Machado, G Pasquarelli-do-Nascimento… - Nutrition & …, 2022 - Springer
Adipose tissues are dynamic tissues that play crucial physiological roles in maintaining
health and homeostasis. Although white adipose tissue and brown adipose tissue are …
health and homeostasis. Although white adipose tissue and brown adipose tissue are …
Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine
B Niemann, S Haufs-Brusberg, L Puetz, M Feickert… - Nature, 2022 - nature.com
Brown adipose tissue (BAT) dissipates energy, and promotes cardiometabolic health. Loss
of BAT during obesity and ageing is a principal hurdle for BAT-centred obesity therapies, but …
of BAT during obesity and ageing is a principal hurdle for BAT-centred obesity therapies, but …
Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis
Adipose tissue undergoes thermogenic remodeling in response to thermal stress and
metabolic cues, playing a crucial role in regulating energy expenditure and metabolic …
metabolic cues, playing a crucial role in regulating energy expenditure and metabolic …
Obesity and endothelial function
M Kajikawa, Y Higashi - Biomedicines, 2022 - mdpi.com
Obesity is a major public health problem and is related to increasing rates of cardiovascular
morbidity and mortality. Over 1.9 billion adults are overweight or obese worldwide and the …
morbidity and mortality. Over 1.9 billion adults are overweight or obese worldwide and the …
Many ways to Rome: exercise, cold exposure and diet—do they all affect BAT activation and WAT browning in the same manner?
AK Scheel, L Espelage, A Chadt - International journal of molecular …, 2022 - mdpi.com
The discovery of functional brown adipose tissue (BAT) in adult humans and the possibility
to recruit beige cells with high thermogenic potential within white adipose tissue (WAT) …
to recruit beige cells with high thermogenic potential within white adipose tissue (WAT) …
[HTML][HTML] Architecture of the outbred brown fat proteome defines regulators of metabolic physiology
Brown adipose tissue (BAT) regulates metabolic physiology. However, nearly all
mechanistic studies of BAT protein function occur in a single inbred mouse strain, which has …
mechanistic studies of BAT protein function occur in a single inbred mouse strain, which has …
Browning epicardial adipose tissue: friend or foe?
E Doukbi, A Soghomonian, C Sengenès, S Ahmed… - Cells, 2022 - mdpi.com
The epicardial adipose tissue (EAT) is the visceral fat depot of the heart which is highly
plastic and in direct contact with myocardium and coronary arteries. Because of its singular …
plastic and in direct contact with myocardium and coronary arteries. Because of its singular …
Epigenetic regulation of white adipose tissue plasticity and energy metabolism by nucleosome binding HMGN proteins
White adipose tissue browning is a key metabolic process controlled by epigenetic factors
that facilitate changes in gene expression leading to altered cell identity. We find that male …
that facilitate changes in gene expression leading to altered cell identity. We find that male …
Adipocyte HIF2α functions as a thermostat via PKA Cα regulation in beige adipocytes
Thermogenic adipocytes generate heat to maintain body temperature against hypothermia
in response to cold. Although tight regulation of thermogenesis is required to prevent energy …
in response to cold. Although tight regulation of thermogenesis is required to prevent energy …