Autophagy is an intracellular self-degradative mechanism which responds to cellular
conditions like stress or starvation and plays a key role in regulating cell metabolism, energy …

Spinal cord injury (SCI) is a severely disabling central nervous system injury with complex
pathological mechanisms that leads to sensory and motor dysfunction. The current treatment …

Introduction Src homology-2-containing protein tyrosine phosphatase 2 (SHP2) is a
ubiquitously expressed, non-receptor protein tyrosine phosphatase encoded by the PTPN11 …

Neuroblastoma (NB) is the most common pediatric extracranial solid tumor arising from
neural crest cells of the developing sympathetic nervous system. Despite marked advances …

Herein, we describe the development of a green, scalable flow Pd-catalyzed aerobic
oxidation for the key step in the synthesis of CPL302415, which is a new PI3Kδ inhibitor …

Aberrant overactivation of the immune system can give rise to chronic and persistent self-
attack, culminating in autoimmune disease. This is currently managed therapeutically using …

Class I phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases. They are super
elevated in many human cancer types and exert their main cellular functions by activating …

Phosphoinositide 3-kinase (PI3K) is the family of lipid kinases participating in vital cellular
processes such as cell proliferation, growth, migration, or cytokines production. Due to the …

Despite substantial improvements in the efficacy of therapeutics used to treat chronic
inflammatory diseases over the last several decades, there is a significant unmet need for …

In the time of a global respiratory pandemic, there has never been a more pertinent time to
improve the current medications responsible for relieving the symptoms of respiratory …