Background In this systematic review, our objective was to assess inflammatory bowel
disease (IBD) patient preferences and perspectives relating to their disease diagnosis …

Chronic pain clinical trials have historically assessed benefit and risk outcomes separately.
However, a growing body of research suggests that a composite metric that accounts for …

Objectives The side effects of dry eye medications can lead to medication non-adherence
and, eventually, to poor outcomes. This study aimed to quantify to what extent the side …

Background A critical gap exits in understanding the dynamics of patient-based benefit-risk
assessment (BRA) of medicines in chronic diseases during the disease journey. Purpose To …

Kidney transplantation has developed to the stage where it is currently the most cost-
effective treatment for patients suffering from end-stage kidney disease (ESKD) and, when …

Abstract Background and objective Anti-TNFs have been shown to significantly improve the
health-related quality of life (HRQoL) in Crohn's disease (CD) patients. The purpose of this …

Background: There is no cure for Crohn's disease (CD). Available treatments and treatment
strategies, particularly anti-TNF, allow healing intestinal lesions and maintaining steroid-free …

Clinical trials, particularly randomised controlled trials (RCTs), have long been considered
the gold-standard means to assess new interventions in inflammatory bowel disease (IBD) …

Background Patients who help choose their health strategies are more adherent and
achieve better health. An important role of the clinician is to verify that a patient's expressed …