[HTML][HTML] Oral delivery of therapeutic peptides and proteins: Technology landscape of lipid-based nanocarriers

S Haddadzadegan, F Dorkoosh… - Advanced drug delivery …, 2022 - Elsevier
The oral administration of therapeutic peptides and proteins is favoured from a patient and
commercial point of view. In order to reach the systemic circulation after oral administration …

[HTML][HTML] Mucosa-interfacing electronics

K Nan, VR Feig, B Ying, JG Howarth, Z Kang… - Nature Reviews …, 2022 - nature.com
The surface mucosa that lines many of our organs houses myriad biometric signals and,
therefore, has great potential as a sensor–tissue interface for high-fidelity and long-term …

Surface modification of lipid-based nanoparticles

Y Xu, T Fourniols, Y Labrak, V Préat, A Beloqui… - ACS …, 2022 - ACS Publications
There is a growing interest in the development of lipid-based nanocarriers for multiple
purposes, including the recent increase of these nanocarriers as vaccine components …

[HTML][HTML] Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems

DA Subramanian, R Langer, G Traverso - Journal of nanobiotechnology, 2022 - Springer
Oral delivery of therapeutics is the preferred route of administration due to ease of
administration which is associated with greater patient medication adherence. One major …

Mucus Penetrating and Cell‐Binding Polyzwitterionic Micelles as Potent Oral Nanomedicine for Cancer Drug Delivery

W Fan, Q Wei, J Xiang, Y Tang, Q Zhou… - Advanced …, 2022 - Wiley Online Library
Orally administrable anticancer nanomedicines are highly desirable due to their easy and
repeatable administration, but are not yet feasible because the current nanomedicine cannot …

Advances and future perspectives in epithelial drug delivery

Y Mohammed, A Holmes, PCL Kwok, T Kumeria… - Advanced Drug Delivery …, 2022 - Elsevier
Epithelial surfaces protect exposed tissues in the body against intrusion of foreign materials,
including xenobiotics, pollen and microbiota. The relative permeability of the various …

Untangling mucosal drug delivery: engineering, designing, and testing nanoparticles to overcome the mucus barrier

J Watchorn, AJ Clasky, G Prakash… - ACS Biomaterials …, 2022 - ACS Publications
Mucus is a complex viscoelastic gel and acts as a barrier covering much of the soft tissue in
the human body. High vascularization and accessibility have motivated drug delivery to …

Chitosan-based oral colon-specific delivery systems for polyphenols: recent advances and emerging trends

S Chen, H Zhu, Y Luo - Journal of Materials Chemistry B, 2022 - pubs.rsc.org
Oral colon-targeted delivery systems (OCDSs) have attracted great attention in the delivery
of active compounds targeted to the colon for the treatment of colon and non-colon diseases …

[HTML][HTML] Mucus-penetrating silk fibroin-based nanotherapeutics for efficient treatment of ulcerative colitis

D Xie, X Zhou, B Xiao, L Duan, Z Zhu - Biomolecules, 2022 - mdpi.com
Oral nanoparticles have been considered a prospective drug delivery carrier against
ulcerative colitis (UC). To enhance the mucus-penetrating capacity and aqueous solubility …

[HTML][HTML] Advancements in rectal drug delivery systems: clinical trials, and patents perspective

R Rathi, Sanshita, A Kumar, V Vishvakarma… - Pharmaceutics, 2022 - mdpi.com
The rectal route is an effective route for the local and systemic delivery of active
pharmaceutical ingredients. The environment of the rectum is relatively constant with low …