[HTML][HTML] Antipsychotic-and anxiolytic-like properties of a multimodal compound JJGW08 in rodents

E Żmudzka, K Lustyk, M Głuch-Lutwin, B Mordyl… - International Journal of …, 2022 - mdpi.com
Schizophrenia is a chronic mental illness, which remains difficult to treat. A high resistance
to the available therapies, their insufficient efficacy, and numerous side effects are the …

Pharmacokinetic, pharmacodynamic, and behavioural studies of deschloroketamine in Wistar rats

K Štefková‐Mazochová, H Danda… - British Journal of …, 2022 - Wiley Online Library
Background and purpose Deschloroketamine (DCK), a structural analogue of ketamine, has
recently emerged on the illicit drug market as a recreational drug with a modestly long …

[HTML][HTML] Clozapine increases nestin concentration in the adult male rat hippocampus: a preliminary study

H Kayir, BW Jenkins, B Alural, JY Khokhar - International Journal of …, 2022 - mdpi.com
Patients with schizophrenia, and rodent models of the disease, both exhibit suppressed
neurogenesis, with antipsychotics possibly enhancing neurogenesis in pre-clinical models …

Neurobehavioral Differences of Valproate and Risperidone on MK‐801 Inducing Acute Hyperlocomotion in Mice

PA Chen, HY Wang, CL Sun, ML Chen… - Behavioural …, 2022 - Wiley Online Library
Objective. The glutamate system plays a major role in the development of neuropsychiatric
disorders such as addiction, epilepsy, dementia, and psychosis. MK‐801 (dizocilpine), an …

Progression of behavioral deficits during periadolescent development differs in female and male DISC1 knockout rats

MJ Glenn, AA Batallán Burrowes, W Yu… - Genes, Brain and …, 2022 - Wiley Online Library
Mutations in the disrupted in schizophrenia‐1 (DISC1) gene are associated with an
increased risk of developing psychological disorders including schizophrenia, bipolar …