4004 ESC Guidelines label use of medication should be limited to situations where it is in
the patient's interest to do so, with regard to the quality, safety, and efficacy of care, and only …

Congenital long QT syndrome (LQTS) encompasses a group of heritable conditions that are
associated with cardiac repolarization dysfunction. Since its initial description in 1957, our …

More than 40 years after the first implantable cardioverter-defibrillator (ICD) implantation,
sudden cardiac death (SCD) still accounts for more than five million deaths worldwide every …

Proper management of patients affected by genetic disorders causing life-threatening
arrhythmias is important for several reasons, including even societal ones, given the …

Objectives This study sought to report our single-center experience with left cardiac
sympathetic denervation (LCSD) for long QT syndrome (LQTS) since 1973. Background …

Many previously unexplained life-threatening ventricular arrhythmias and sudden cardiac
deaths (SCDs) in young individuals are now recognized to be genetic in nature and are …

Electrical storm, characterized by repetitive ventricular tachycardia/ventricular fibrillation
over a short period, is becoming more common with widespread use of implantable …

In the human heart, the rapid delayed rectifier K+ current (I Kr) contributes significantly to
ventricular action potential (AP) repolarization and to set the duration of the QT interval of the …

Sudden death is a rare event in the pediatric population but with a social shock due to its
presentation as the first symptom in previously healthy children. Comprehensive autopsy in …

Long QT syndrome (LQTS) is an inherited (autosomal dominant) channelopathy associated
with susceptibility to ventricular arrhythmias due to malfunction of ion channels in …