Arthrofibrosis, or rigid contracture of major articular joints, is a significant morbidity of many
neurodegenerative disorders. The pathogenesis depends on the mechanism and severity of …

This review focuses upon the implications of the Notch signaling pathway in muscular
dystrophies, particularly Duchenne muscular dystrophy (DMD): a pervasive and catastrophic …

Purpose Measuring the physical activity of adults with progressive muscle diseases is
important to inform clinical practice, for activity recommendations and for outcomes …

CHKB encodes one of two mammalian choline kinase enzymes that catalyze the first step in
the synthesis of the membrane phospholipid phosphatidylcholine. In humans and mice …

Abstract Advancements in Polymerase Chain Reaction (PCR) technology and other
techniques like Deoxyribonucleic acid (DNA) signal and target amplification have become …

Limb girdle muscular dystrophy (LGMD) is a type of Muscular dystrophy (MD),
heterogeneous devastating complex genetic disorders causing progressive weakness and …

Understanding the way genes work amongst individuals and across generations to shape
form and function is a common theme for many genetic studies. The recent advances in …

High-throughput screening enables the discovery of disease-modifying small molecules.
Here, we describe the development of a scalable, cell-based assay to screen for small …

The muscular dystrophies are a group of inherited conditions that are associated with
progressive weakness and wasting of muscle tissue. Muscular dystrophies are placed under …

Myopathies are genetically inherited muscle degenerative disorders that mainly cause
muscle weakness and a more or less marked muscle wasting (atrophy), although rare but …