Abstract During SARS-CoV-2 infection, the innate immune response can be inhibited or
delayed, and the subsequent persistent viral replication can induce emergency signals that …

Cytokines signal through cell surface receptor dimers to initiate activation of intracellular
Janus kinases (JAKs). We report the 3.6-angstrom–resolution cryo–electron microscopy …

Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, arising from
immature lymphocytes that show uncontrolled proliferation and arrested differentiation …

The IL-17 family of cytokines and receptors have central roles in host defence against
infection and development of inflammatory diseases. The compositions and structures of …

The capacity to regulate the signaling amplitude of membrane receptors in a user-defined
manner would open various opportunities for precise biological study and therapy. While …

Single-molecule imaging provides a powerful way to study biochemical processes in live
cells, yet it remains challenging to track single molecules while simultaneously detecting …

Localization and tracking of individual receptors by single-molecule imaging opens unique
possibilities to unravel the assembly and dynamics of signaling complexes in the plasma …

JAK2 is a non-receptor tyrosine kinase that regulates hematopoiesis through the JAK-STAT
pathway. The pseudokinase domain (JH2) is an important regulator of the activity of the …

The pursual of novel anticancer molecules from natural sources has gained worthwhile
appreciation, and a significant fraction of conceptual knowledge has revolutionized our …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, first notified
in China, has spread around the world causing high morbidity and mortality, which is due to …